Results 21 to 30 of about 5,161 (196)

Persisting Region-Specific Microglia Activation and Synaptic Imbalance During Remission in a DSS-Induced Colitis Model. [PDF]

Glia
Relapsing colitis region‐specific microglial states beyond remission. Cortical microglia remain pro‐inflammatory and synapse‐disruptive, while hippocampal microglia shift toward a reparative program that maintains neuronal circuit stability. ABSTRACT Ulcerative colitis (UC) patients experience cycles of active gut inflammation and remission, with ...
Morton L, Villafuerte LE, Garza AP, Lindemann N, Wider-Eberspächer E, Bruder D, Dunay IR.   +6 more
europepmc   +2 more sources

Gephyrin: a central GABAergic synapse organizer [PDF]

Experimental & Molecular Medicine, 2015
Gephyrin is a central element that anchors, clusters and stabilizes glycine and γ-aminobutyric acid type A receptors at inhibitory synapses of the mammalian brain. It self-assembles into a hexagonal lattice and interacts with various inhibitory synaptic proteins. Intriguingly, the clustering of gephyrin, which is regulated by multiple posttranslational
Gayoung, Choii, Jaewon, Ko
openaire   +2 more sources

Novel Functional Properties of Missense Mutations in the Glycine Receptor β Subunit in Startle Disease

Frontiers in Molecular Neuroscience, 2021
Startle disease is a rare disorder associated with mutations in GLRA1 and GLRB, encoding glycine receptor (GlyR) α1 and β subunits, which enable fast synaptic inhibitory transmission in the spinal cord and brainstem.
Inken Piro, Anna-Lena Eckes, Vikram Babu Kasaragod, Claudia Sommer, Robert J. Harvey, Robert J. Harvey, Natascha Schaefer, Carmen Villmann   +7 more
doaj   +1 more source

Receptors, gephyrin and gephyrin‐associated proteins: novel insights into the assembly of inhibitory postsynaptic membrane specializations [PDF]

The Journal of Physiology, 2000
The synaptic localization of ion channel receptors is essential for efficient synaptic trans‐mission and the precise regulation of diverse neuronal functions, such as signal integration and synaptic plasticity. Emerging evidence points to an important role of cytoskeleton‐associated proteins that assemble receptors and components of the subsynaptic ...
M, Kneussel, H, Betz
openaire   +2 more sources

Complex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity

Nature Communications, 2022
The protein gephyrin is involved in organizing synapses. Here, the authors show how different transcripts of gephyrin form and regulate inhibitory synapses.
Raphaël Dos Reis, Etienne Kornobis, Alyssa Pereira, Frederic Tores, Judit Carrasco, Candice Gautier, Céline Jahannault-Talignani, Patrick Nitschké, Christian Muchardt, Andreas Schlosser, Hans Michael Maric, Fabrice Ango, Eric Allemand   +12 more
doaj   +1 more source

The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering [PDF]

, 2004
Glycine receptors (GlyRs) and specific subtypes of GABA(A) receptors are clustered at synapses by the multidomain protein gephyrin, which in turn is translocated to the cell membrane by the GDP-GTP exchange factor collybistin.
Ward, H, Harvey, R.J., Alldred, Melissa J., Smart, T.G., Luscher, B, Duguid, Ian C, Lingenfelter, S E, Duguid, IC, Ward, H., Lingenfelter, Sue E., Alldred, M.J., Harvey, Robert J., Pearce, B R, Lundgren, J.D., Harvey, K, Owen, Michael John, Pearce, Brian R., Beatty, S.E., Smart, Trevor G., Owens, Max J., Keep, N H, Harvey, RJ, Lingenfelter, S.E., Harvey, Robert J, Keep, NH, Lundgren, J, Owen, MJ, Lund University., Ward, Hamish, Smart, T G, Pearce, B.R., Lüscher, Bernhard, Beatty, Sarah E., Lingenfelter, SE, Lundgren, Johan,, Keep, Nicholas H., Lundgren, Johan, Luscher, B., Harvey, K., Smart, TG, Alldred, M J, Beatty, SE, Owen, M J, Beatty, S E, Alldred, MJ, Rees, MI, Harvey, Kirsten, Duguid, I C, Rees, Mark I., Rees, M I, Duguid, I.C., Pearce, BR, Mark Rees, Rees, M.I.   +53 more
core   +1 more source

Hippocampal Astrocytes Impact Postnatal Development of Inhibitory Connections, Parvalbumin Levels, Social, and Spatial Navigation Behaviors in a Mouse Model of Fragile X Syndrome. [PDF]

J Neurochem
Astrocyte‐specific postnatal deletion of Fmr1 affects GABAergic gene expression and phasic inhibition of CA1 neurons in the hippocampus. While GABA transport in astrocytes does not alter tonic inhibition of CA1 pyramidal cells, it affects PV levels and is implicated in impaired spatial memories and social behaviors in astrocyte‐specific Fmr1 cKO mice ...
Wagner VA, Maples S, Thapa R, Wimberly J, Pettijohn E, Varallo A, Rais M, Sutley-Koury S, Hickmott P, Ethell IM.   +9 more
europepmc   +2 more sources

Phytomedicine in Disease Management: In-Silico Analysis of the Binding Affinity of Artesunate and Azadirachtin for Malaria Treatment

Frontiers in Pharmacology, 2021
In the rural communities of sub-Saharan African (sSA) countries, malaria is being managed using phytocompounds. Artesunate is reported to inhibit Gephyrin E, a central, multi-domain scaffolding protein of inhibitory post-synapses.
Michael P. Okoh, Michael P. Okoh, Rajeev K. Singla, Chijioke Madu, Opeyemi Soremekun, Opeyemi Soremekun, Johnson Adejoh, Lukman A. Alli, Bairong Shen   +8 more
doaj   +1 more source

Autoimmunity to Gephyrin in Stiff-Man Syndrome [PDF]

Neuron, 2000
Stiff-Man syndrome (SMS) is a rare disease of the central nervous system (CNS) characterized by chronic rigidity, spasms, and autoimmunity directed against synaptic antigens, most often the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD). In a subset of cases, SMS has an autoimmune paraneoplastic origin.
Butler, Margaret Husta, Hayashi, Akito, Ohkoshi, Norio, Villmann, Carmen, Becker, Cord-Michael, Feng, Guoping, De Camilli, Pietro, Solimena, Michele   +7 more
openaire   +2 more sources

Gephyrin: a scaffold that builds a phase at the inhibitory postsynapses [PDF]

Cell Research, 2020
The scaffolding protein gephyrin is a core component of many inhibitory synapses. Bai and colleagues now show that phase separation of gephyrin with the subunits of both glycine and GABA receptors underlies the formation of postsynaptic sheets at the inhibitory ...
Christian Hoffmann, Dragomir Milovanovic
openaire   +3 more sources