Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse [PDF]
Cell Reports, 2019 Summary: Inhibitory synapses mediate the majority of synaptic inhibition in the brain, thereby controlling neuronal excitability, firing, and plasticity.
Katharine R Smith +2 more
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Mimicking Bidirectional Inhibitory Synapse Using a Porous-Confined Ionic Memristor with Electrolyte/Tris(4-aminophenyl)amine Neurotransmitter [PDF]
Advanced ScienceIonic memristors can emulate brain‐like functions of biological synapses for neuromorphic technologies. Apart from the widely studied excitatory‐excitatory and excitatory‐inhibitory synapses, reports on memristors with the inhibitory‐inhibitory synaptic ...
Zhe Zhou, Juqing Liu, Zixi He
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ErbB4 promotes inhibitory synapse formation by cell adhesion, independent of its kinase activity [PDF]
Translational Psychiatry, 2021 The precise control of the nervous system function under the vitality of synapses is extremely critical. Efforts have been taken to explore the underlying cellular and molecular mechanisms for synapse formation.
Bin Luo +9 more
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Stable excitatory-inhibitory synapse balance despite dynamic turnover [PDF]
eLifeDiverse synaptic connections self-organize into neural circuits during brain development. A balance between excitatory and inhibitory synaptic function is required for information processing by these neural circuits.
Krassimira A Garbett +4 more
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Valproic acid-exposed astrocytes impair inhibitory synapse formation and function [PDF]
Scientific Reports, 2021 Valproic acid (VPA) is widely prescribed to treat epilepsy. Maternal VPA use is, however, clinically restricted because of the severe risk that VPA may cause neurodevelopmental disorders in offspring, such as autism spectrum disorder.
Kotomi Takeda +8 more
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Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration [PDF]
Frontiers in Cellular Neuroscience, 2019 Synapse loss is an early feature shared by many neurodegenerative diseases, and it represents the major correlate of cognitive impairment. Recent studies reveal that microglia and astrocytes play a major role in synapse elimination, contributing to ...
Christopher M. Henstridge +4 more
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Cell Reports, 2018 Summary: Normal brain functions depend on the balanced development of excitatory and inhibitory synapses. Our knowledge of the molecular mechanisms underlying inhibitory synapse formation is limited.
Jun Xia, Xiaobo Liu, Shengwang Du
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Distinct functional domains of Dystroglycan regulate inhibitory synapse formation and maintenance in cerebellar Purkinje cells [PDF]
Communications BiologyDystroglycan is a cell adhesion molecule that localizes to synapses throughout the nervous system. While Dystroglycan is required to maintain inhibitory synapses from cerebellar molecular layer interneurons (MLIs) onto Purkinje cells (PCs) whether ...
Jennifer N. Jahncke +2 more
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Inhibitory Synapse Formation at the Axon Initial Segment [PDF]
Frontiers in Molecular Neuroscience, 2019 The axon initial segment (AIS) is the site of action potential (AP) initiation in most neurons and is thus a critical site in the regulation of neuronal excitability.
Anna J. Nathanson +4 more
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Frontiers in Synaptic Neuroscience, 2022 The nanoscale architecture of synapses has been investigated using multiple super-resolution methods, revealing a common modular structure for scaffolds, neurotransmitter receptors, and presynaptic proteins. This fundamental organization of proteins into
Katharine R Smith +2 more
exaly +3 more sources