Neurexins and their ligands at inhibitory synapses
Frontiers in Synaptic Neuroscience, 2022 Since the discovery of neurexins (Nrxns) as essential and evolutionarily conserved synaptic adhesion molecules, focus has largely centered on their functional contributions to glutamatergic synapses. Recently, significant advances to our understanding of
Emma E. Boxer, Jason Aoto
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Whisker Deprivation Drives Two Phases of Inhibitory Synapse Weakening in Layer 4 of Rat Somatosensory Cortex. [PDF]
PLoS ONE, 2016 Inhibitory synapse development in sensory neocortex is experience-dependent, with sustained sensory deprivation yielding fewer and weaker inhibitory synapses.
Melanie A Gainey +3 more
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Synapse-specific inhibitory control of hippocampal feedback inhibitory circuit [PDF]
Frontiers in Cellular Neuroscience, 2010 Local circuit and long-range GABAergic projections provide powerful inhibitory control over the operation of hippocampal inhibitory circuits, yet little is known about the input- and target-specific organization of interacting inhibitory networks in ...
Simon eChamberland +6 more
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Inhibitory receptor signaling destabilizes immunological synapse formation in primary NK cells [PDF]
Frontiers in Immunology, 2013 Upon engagement of their cognate class I major histocompatibility complex (MHC) ligands, receptors containing immunotyrosine-based inhibitory motifs (ITIMs) transduce signals that block cytolytic and inflammatory responses.
Thushara P Abeyweera +2 more
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Building up the inhibitory synapse [PDF]
Frontiers in Cellular Neuroscience, 2013 “Building up the inhibitory synapse” is a complex phenomenoninvolving a variety of dynamically regulated molecular andcellular processes whose nature is still largely unknown.Understanding the role of different proteins in controllingsynapses formation and stabilization may help elucidating, at thenetwork level, the mechanisms by which inhibitory ...
Enrico eCherubini, Paola eZacchi
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Cell-autonomous reduction of CYFIP2 changes dendrite length, dendritic protrusion morphology, and inhibitory synapse density in the hippocampal CA1 pyramidal neurons of 17-month-old mice [PDF]
Animal Cells and SystemsThe cytoplasmic FMR1-interacting protein 2 (CYFIP2) have diverse molecular functions in neurons, including the regulation of actin polymerization, mRNA translation, and mitochondrial morphology and function.
Yoonhee Kim +5 more
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An NMDA Receptor-Dependent Mechanism Underlies Inhibitory Synapse Development [PDF]
Cell Reports, 2016 In the mammalian brain, GABAergic synaptic transmission provides inhibitory balance to glutamatergic excitatory drive and controls neuronal output. The molecular mechanisms underlying the development of GABAergic synapses remain largely unclear. Here, we
Xinglong Gu, Liang Zhou, Wei Lu
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NKp46 clusters at the immune synapse and regulates NK cell polarization [PDF]
Frontiers in Immunology, 2015 Natural killer cells play an important role in first-line defense against tumor and virus-infected cells. The activity of NK cells is tightly regulated by a repertoire of cell-surface expressed inhibitory and activating receptors.
Uzi eHadad +6 more
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Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models. [PDF]
Nat Aging, 2022 Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependent ...
Dejanovic B +21 more
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Astrocyte-secreted neurocan controls inhibitory synapse formation and function [PDF]
NeuronDolores Irala +2 more
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