Results 51 to 60 of about 5,161 (196)
Cell Reports, 2020 Summary: Gephyrin interacts with various GABAergic synaptic proteins to organize GABAergic synapse development. Among the multitude of gephyrin-binding proteins is IQSEC3, a recently identified component at GABAergic synapses that acts through its ADP ...
Seungjoon Kim +10 more
doaj +1 more source
Endogenous Protein Tagging in Postmitotic Neurons via Lentiviral and Adeno‐associated Virus Delivery
Current Protocols, Volume 6, Issue 10, October 2026.Abstract This protocol describes a method for endogenous protein tagging in postmitotic primary neurons using homology‐independent targeted integration (HITI), a CRISPR/Cas9‐based approach that exploits non‐homologous end joining (NHEJ). Unlike homology‐directed repair (HDR), HITI does not require cell division, making it uniquely suited for ...
Lorena Benedetti +3 more
wiley +1 more source
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission
, 2017 γ-Aminobutyric acid type A and glycine receptors are the major mediators of fast synaptic inhibition in the human central nervous system and are established drug targets.
Franziska Neubert +15 more
core +1 more source
Mass spectrometric analysis of glycine receptor-associated gephyrin splice variants
, 2021 Gephyrin is an ubiquitously expressed protein that, in the nervous system, is essential for synaptic anchoring of glycine receptors (GlyRs) and major GABAA receptor subtypes.
Meyer, Björn +4 more
core +1 more source
Frontiers in Molecular Neuroscience, 2019 The recruitment of inhibitory GABAA receptors to neuronal synapses requires a complex interplay between receptors, neuroligins, the scaffolding protein gephyrin and the GDP-GTP exchange factor collybistin (CB). Collybistin is regulated by protein-protein
Tzu-Ting Chiou +10 more
doaj +1 more source
Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States
Glia, Volume 74, Issue 10, October 2026.Proximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
João Baltar +3 more
wiley +1 more source
Nature Communications, 2016 Gephyrin is a cytoplasmic scaffolding protein that selectively forms postsynaptic scaffolds at GABAergic and glycinergic synapses. Here the authors characterize regulatory mechanisms determining gephyrin scaffolding and GABAA receptor synaptic ...
Himanish Ghosh +14 more
doaj +1 more source
Gephyrin Oligomerization Controls GlyR Mobility and Synaptic Clustering [PDF]
Journal of Neuroscience, 2009 High local concentrations of glycine receptors (GlyRs) at inhibitory postsynaptic sites are achieved through their binding to the scaffold protein gephyrin. The N- and C-terminal domains of gephyrin are believed to trimerize and dimerize, respectively, thus contributing to the formation of submembranous gephyrin clusters at synapses.
Martino, Calamai +6 more
openaire +2 more sources
Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.Physiological and Pathological Alterations in PV+ Neurons: Under physiological conditions, PV+ interneurons exhibit fast‐spiking properties and generate gamma oscillations at the cost of high energy consumption. In AD, PV+ neurons display abnormalities in ion channels, dendrites, neurotransmission, energy metabolism, and neural oscillations, ultimately
Mengyan Wu +5 more
wiley +1 more source
Neuronal cotransport of glycine receptor and the scaffold protein gephyrin [PDF]
The Journal of Cell Biology, 2006 The dynamics of postsynaptic receptor scaffold formation and remodeling at inhibitory synapses remain largely unknown. Gephyrin, which is a multimeric scaffold protein, interacts with cytoskeletal elements and stabilizes glycine receptors (GlyRs) and individual subtypes of γ-aminobutyric acid A receptors at inhibitory postsynaptic sites.
Maas, Christoph +5 more
openaire +2 more sources