Results 71 to 80 of about 5,161 (196)
FEBS Open Bio, Volume 16, Issue 7, Page 1340-1357, July 2026.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Analysis of the promoter region of the murine gephyrin gene
FEBS Letters, 1997 © 1997 Federation of European Biochemical Societies.
Ramming, Markus +2 more
openaire +2 more sources
Neurobiology of Disease, 2014 Gephyrin is a postsynaptic scaffolding protein, essential for the clustering of glycine and γ-aminobutyric acid type-A receptors (GABAARs) at inhibitory synapses. An impairment of GABAergic synaptic inhibition represents a key pathway of epileptogenesis.
Borislav Dejanovic +17 more
doaj +1 more source
Advanced Science, Volume 13, Issue 41, 22 July 2026.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Gephyrin suppresses lung squamous cell carcinoma development by reducing mTOR pathway activation
Cancer Management and Research, 2019 Xiang Zhang,1,2 Dezhi Cheng,1,2 Yu Liu,1,2 Yuanbo Wu,2 Zhifeng He1,21Department of Thoracic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 2Department of Cardiothoracic Surgery ...
Zhang X, Cheng D, Liu Y, Wu Y, He Z
doaj
BMC Research Notes, 2010 Background Collybistin (CB), a neuron-specific guanine nucleotide exchange factor, has been implicated in targeting gephyrin-GABAA receptors clusters to inhibitory postsynaptic sites.
De Paula Vanessa J +3 more
doaj +1 more source
Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy
Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva +5 more
wiley +1 more source
Small, Volume 22, Issue 41, 22 July 2026.We present a pathology‐responsive, activity‐based prodrug strategy that tackles multiple hallmarks of Alzheimer's disease (AD). Rationally designed BE compounds convert under oxidative stress into redox‐active aminophenols, neutralizing ROS and redirecting both metal‐free and metal‐bound Aβ aggregation.
Jimin Lee +13 more
wiley +1 more source
Targeting GABAAR-Associated Proteins: New Modulators, Labels and Concepts
Frontiers in Molecular Neuroscience, 2019 γ-aminobutyric acid type A receptors (GABAARs) are the major mediators of synaptic inhibition in the brain. Aberrant GABAAR activity or regulation is observed in various neurodevelopmental disorders, neurodegenerative diseases and mental illnesses ...
Vladimir Khayenko +3 more
doaj +1 more source
Innervation Pattern of Inhibitory Projection Neurons in the Bird Sound Localization Circuit
Journal of Comparative Neurology, Volume 534, Issue 6, June 2026.We analyzed the innervation pattern of individual axons from SON neurons within the chicken nucleus laminaris (NL). The size of inhibitory SON axonal arborizations varies widely and lacks specific targeting to dendritic layers or to the tonotopic and ITD axes within NL.
Kathryn M. Tabor +2 more
wiley +1 more source