Results 91 to 100 of about 5,161 (196)

IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation

, 2016
Gephyrin is a central scaffold protein that mediates development, function, and plasticity of mammalian inhibitory synapses by interacting with various inhibitory synaptic proteins. Here, we show that IQSLC3, a guanine nucleotide exchange factor for ARE6,
Choii, Gayoung, Mori, Takuma, Kim, Eunjoon, Papadopoulos, Theofilos, Tabuchi, Katsuhiko, Kim, Dongwook, Kang, Hyeyeon, Ko, Jaewon, Lee, Yeunkum, Jeon, Sangmin, Um, Ji Won, Park, Dongseok, Yoo, Taesun, Gayoung Choii, Dongseok Park, Hyeyeon Kang, Yeunkum Lee, Taesun Yoo, Eunjoon Kim, Theofilos Papadopoulos, TKatsuhiko abuchi, Dongwook Kim, 엄지원, Ji Won Um, Sangmin Jeon, Jaewon Ko, Takuma Mori   +26 more
core   +2 more sources

Dissection of signaling pathways regulating TrkB-dependent gephyrin clustering

Frontiers in Molecular Neuroscience
IntroductionThe TrkB receptor is known for its role in regulating excitatory neuronal plasticity. However, accumulating evidence over the past decade has highlighted the involvement of TrkB in regulating inhibitory synapse stability and plasticity ...
Lisa-Sophie Wüstner, Lisa-Sophie Wüstner, Simone Beuter, Martin Kriebel, Hansjürgen Volkmer, Hansjürgen Volkmer   +5 more
doaj   +1 more source

Splice-specific functions of gephyrin in molybdenum cofactor biosynthesis

, 2008
Gephyrin is a multifunctional protein involved in the clustering of inhibitory neuroreceptors. In addition, gephyrin catalyses the last step in molybdenum cofactor (Moco) biosynthesis essential for the activities of Mo-dependent enzymes such as sulfite ...
Smolinsky, B., Eichler, S.A., Schwarz, G., Burchmeier, S., Meier, J.C.   +4 more
core   +1 more source

Modulation of Gephyrin-Glycine Receptor Affinity by Multivalency

, 2016
Gephyrin is a major determinant for the accumulation and anchoring of glycine receptors (GlyRs) and the majority of γ-aminobutyric acid type A receptors (GABAARs) at postsynaptic sites.
Hermann Schindelin (440504), Hans Michael Maric (1716547), Vikram Babu Kasaragod (1716550)   +2 more
core   +1 more source

Gephyrin and the postsynaptic GABAergic complex

, 2007
Although gephyrin is an important postsynaptic scaffolding protein at GABAergic synapses, the role of gephyrin for GABAergic synapse formation and/or maintenance is still under debate.
Yu, Wendou
core   +1 more source

Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation

Communications Biology
Neuroligin-2 (Nlgn2) is a key synaptic adhesion protein at virtually all GABAergic synapses, which recruits GABAARs by promoting assembly of the postsynaptic gephyrin scaffold.
Tommaso Zeppillo, Heba Ali, Sowbarnika Ravichandran, Tamara C. Ritter, Sally Wenger, Francisco J. López-Murcia, Erinn Gideons, Janetti Signorelli, Michael J. Schmeisser, Jens Wiltfang, JeongSeop Rhee, Nils Brose, Holger Taschenberger, Dilja Krueger-Burg   +13 more
doaj   +1 more source

Subsynaptic Domains in Super-Resolution Microscopy: The Treachery of Images

Frontiers in Molecular Neuroscience, 2019
The application of super-resolution optical microscopy to investigating synaptic structures has revealed a highly heterogeneous and variable intra-synaptic organization.
Xiaojuan Yang, Christian G. Specht
doaj   +1 more source

A Conserved Tyrosine Residue in Slitrk3 Carboxyl-Terminus Is Critical for GABAergic Synapse Development

Frontiers in Molecular Neuroscience, 2019
Single-passing transmembrane protein, Slitrk3 (Slit and Trk-like family member 3, ST3), is a synaptic cell adhesion molecule highly expressed at inhibitory synapses.
Jun Li, Wenyan Han, Kunwei Wu, Yuping Derek Li, Qun Liu, Wei Lu   +5 more
doaj   +1 more source

Structural and biochemical characterization of gephyrin and various gephyrin-ligand complexes [PDF]

, 2014
Efficient synaptic neurotransmission requires the exact apposition of presynaptic terminals and matching neurotransmitter receptor clusters on the postsynaptic side. The receptors are embedded in the postsynaptic density, which also contains scaffolding and regulatory proteins that ensure high local receptor concentrations.
openaire  

Diffusion dynamics of synaptic molecules during inhibitory postsynaptic plasticity

Frontiers in Cellular Neuroscience, 2014
The plasticity of inhibitory transmission is expected to play a key role in the modulation of neuronal excitability and network function. Over the last two decades, the investigation of the determinants of inhibitory synaptic plasticity has allowed ...
Enrica Maria ePetrini, Andrea eBarberis
doaj   +1 more source