Results 101 to 110 of about 5,161 (196)

Gephyrin splice variant-specific recruitment of GlyR α1-βE9A-3.

, 2016
(A-E) Images of transfected primary hippocampal neurons show HA-α1-βE9A-3 and EGFP-tagged gephyrin splice variants. (A-D) No or apparently occasional overlap between HA-α1-βE9A-3 clusters and large aggregates of the over-expressed denoted different ...
Günter Schwarz (2211511), Jochen C. Meier (598189), Nora Grünewald (2211517), Xiantian You (2211523), Heinz Krestel (2211526), Aline Winkelmann (2211520), Carola A. Haas (149170), Ute Häussler (2211514), Wei Chen (23863)   +8 more
core   +1 more source

Structure–Function Relationships of Glycine and GABAA Receptors and Their Interplay With the Scaffolding Protein Gephyrin

Frontiers in Molecular Neuroscience, 2018
Glycine and γ-aminobutyric acid (GABA) are the major determinants of inhibition in the central nervous system (CNS). These neurotransmitters target glycine and GABAA receptors, respectively, which both belong to the Cys-loop superfamily of pentameric ...
Vikram B. Kasaragod, Hermann Schindelin
doaj   +1 more source

Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse

Cell Reports, 2019
Summary: Inhibitory synapses mediate the majority of synaptic inhibition in the brain, thereby controlling neuronal excitability, firing, and plasticity.
Kevin C. Crosby, Sara E. Gookin, Joshua D. Garcia, Katlin M. Hahm, Mark L. Dell’Acqua, Katharine R. Smith   +5 more
doaj   +1 more source

Complex Formation between the Postsynaptic Scaffolding Protein Gephyrin, Profilin, and Mena: A Possible Link to the Microfilament System

, 2003
Gephyrin is an essential component of the postsynaptic cortical protein network of inhibitory synapses. Gephyrin-based scaffolds participate in the assembly as well as the dynamics of receptor clusters by connecting the cytoplasmic domains of glycine and
Günter Schwarz, Ralf R. Mendel, Brigitte M. Jockusch, Kerstin Berhörster, Ralph Nawrotzki, Hermann Schindelin, Kathrin Schlüter, Joachim Kirsch, Torsten Giesemann, Nils Schrader, Martin Rothkegel   +10 more
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Glycine receptors expression in rat spinal cord and dorsal root ganglion in prostaglandin E2 intrathecal injection models

BMC Neuroscience, 2018
Background Glycine receptors (GlyRs) are involved in the development of spinal pain sensitization. The GlyRα3 subunit has recently emerged as a key factor in inflammatory pain pathways in the spinal cord dorsal horn (DH).
Hung-Chen Wang, Kuang-I Cheng, Pei-Ru Chen, Kuang-Yi Tseng, Aij-Lie Kwan, Lin-Li Chang   +5 more
doaj   +1 more source

miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity

EMBO Reports
Activity-dependent protein synthesis is crucial for long-lasting forms of synaptic plasticity. However, our understanding of translational mechanisms controlling GABAergic synapses is limited. One distinct form of inhibitory long-term potentiation (iLTP)
Theresa M Welle, Dipen Rajgor, Dean J Kareemo, Joshua D Garcia, Sarah M Zych, Sarah E Wolfe, Sara E Gookin, Tyler P Martinez, Mark L Dell’Acqua, Christopher P Ford, Matthew J Kennedy, Katharine R Smith   +11 more
doaj   +1 more source

Charakterisierung der Gephyrin – GABA\(_A\)/Glycin-Rezeptor Interaktion mithilfe von Peptidbibliotheken

γ-Aminobutyric acid type A and glycine receptors are the major mediators of fast synaptic inhibition in the mammalian brain. They assemble as hetero- as well as homopentamers and are targeted to functionally diverse synapse types by intracellularly ...
Peck, Violetta
core   +1 more source

Direct binding of GABA(A) receptor β2 and β3 subunits to gephyrin

, 2013
GABAergic transmission is essential to brain function, and a large repertoire of GABA type A receptor (GABA(A) R) subunits is at a neuron's disposition to serve this function.
Foerstera, B., Guenter Schwarz, Benjamin Förstera, Meier, J.C., Jochen C. Meier, Birthe Smolinsky, Ines Neundorf, Smolinsky, B., Schwarz, G., Sarah Kowalczyk, Aline Winkelmann, Kowalczyk, S., Winkelmann, A., Neundorf, I.   +13 more
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Molecular basis of gephyrin clustering at inhibitory synapses : the role of gephyrin sub-domain oligomerizations

, 2007
Die Verarbeitung von Informationen im zentralen Nervensystem beruht auf dem Zusammenspiel von erregender und hemmender Neurotransmission. Die Übertragung von Signalen zwischen Neuronen erfolgt chemisch über die Ausschüttung von Neurotransmittern an ...
Saiyed, T., Saiyed, Taslimarif
core  

Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors

, 2015
Gephyrin is the central scaffolding protein for inhibitory neurotransmitter receptors in the brain. Here we describe the development of dimeric peptides that inhibit the interaction between gephyrin and these receptors, a process which is fundamental to ...
Strømgaard, Kristian, Kasaragod, V.B., Schindelin, Hermann, Maric, H.M., Stromgaard, K., Kedström, Linda Maria Haugaard, Hausrat, T.J., Hausrat, Torben Johann, Kneussel, M., Maric, Hans-Michael, Schindelin, H., Kneussel, Matthias, Kasaragod, Vikram Babu, Haugaard Kedstrom, L.   +13 more
core   +1 more source