Results 81 to 90 of about 5,161 (196)

Gephyrin: where do we stand, where do we go?

, 2008
Gephyrin is a multifunctional protein responsible for molybdenum cofactor synthesis and the clustering of glycine and GABA(A) receptors at inhibitory synapses.
Harvey, R J, Schwarz, G, Harvey, Robert J, Fritschy, J M, Schwarz G, Harvey RJ, Fritschy JM   +6 more
core   +1 more source

Gephyrin: a master regulator of neuronal function?

Nature Reviews Neuroscience, 2014
The neurotransmitters GABA and glycine mediate fast synaptic inhibition by activating ligand-gated chloride channels--namely, type A GABA (GABA(A)) and glycine receptors. Both types of receptors are anchored postsynaptically by gephyrin, which self-assembles into a scaffold and interacts with the cytoskeleton.
Tyagarajan Shiva K, Fritschy Jean-Marc
openaire   +3 more sources

The gephyrin scaffold modulates cortical layer 2/3 pyramidal neuron responsiveness to single whisker stimulation

Scientific Reports
Gephyrin is the main scaffolding protein at inhibitory postsynaptic sites, and its clusters are the signaling hubs where several molecular pathways converge.
Yuan-Chen Tsai, Mohammad Hleihil, Kanako Otomo, Andrin Abegg, Anna Cavaccini, Patrizia Panzanelli, Teresa Cramer, Kim David Ferrari, Matthew J. P. Barrett, Giovanna Bosshard, Theofanis Karayannis, Bruno Weber, Shiva K. Tyagarajan, Jillian L. Stobart   +13 more
doaj   +1 more source

Strukturelle und biochemische Charakterisierung von Gephyrin und verschiedenen Gephyrin-Liganden-Komplexen

, 2014
Efficient synaptic neurotransmission requires the exact apposition of presynaptic terminals and matching neurotransmitter receptor clusters on the postsynaptic side.
Sander, Bodo
core   +1 more source

Neurexin-1β Binding to Neuroligin-1 Triggers the Preferential Recruitment of PSD-95 versus Gephyrin through Tyrosine Phosphorylation of Neuroligin-1

Cell Reports, 2013
Adhesion between neurexin-1β (Nrx1β) and neuroligin-1 (Nlg1) induces early recruitment of the postsynaptic density protein 95 (PSD-95) scaffold; however, the associated signaling mechanisms are unknown.
Grégory Giannone, Magali Mondin, Dolors Grillo-Bosch, Béatrice Tessier, Edouard Saint-Michel, Katalin Czöndör, Matthieu Sainlos, Daniel Choquet, Olivier Thoumine   +8 more
doaj   +1 more source

The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity

Autism Research, Volume 19, Issue 5, May 2026.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors. Pathogenic mutations in UBE3B result in neurodevelopmental disease, including intellectual disability, lack of speech, and ASD.
Shayal Vashisth, Aleya Shedd, Ariel Aiken, Solmi Cheon, Josh Bandopadhay, Kiran Kaur, Kimberly M. Huber, Maria H. Chahrour   +7 more
wiley   +1 more source

Enrichment of GABAA receptor α-subunits on the axonal initial segment shows regional differences

Frontiers in Cellular Neuroscience, 2016
Although it is generally recognized that certain α-subunits of γ-aminobutyric acid type A receptors (GABAARs) form enriched clusters on the axonal initial segment (AIS), the degree to which these clusters vary in different brain areas is not well known ...
Yudong eGao, Scott Allyn Heldt
doaj   +1 more source

Gephyrin is palmitoylated by DHHC-12.

, 2014
(a) Individual HA-tagged DHHC proteins or GST-HA as control were co-expressed with gephyrin-GFP for 24 h in HEK293 cells and analyzed with the ABE assay. Omitting hydroxylamine demonstrated specify of the assay.
Borislav Dejanovic (598187), Silvia Ebert (598188), Guenter Schwarz (510946), Jochen C. Meier (598189), Marcus Semtner (249048), Franziska Neuser (424593), Tobias Lamkemeyer (159366), Bernhard Lüscher (4729437)   +7 more
core   +1 more source

Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses

eLife, 2016
Neuroligins (NLGNs) are postsynaptic cell adhesion molecules that interact trans-synaptically with neurexins to mediate synapse development and function. NLGN2 is only at inhibitory synapses while NLGN3 is at both excitatory and inhibitory synapses.
Quynh-Anh Nguyen, Meryl E Horn, Roger A Nicoll   +2 more
doaj   +1 more source

Gephyrin dominant-negative chimera decreased gephyrin and GABA_AR γ2 clustering.

, 2012
(A) Hippocampal cultured neurons from mRFP-gephyrin knock-in mice transfected with GFP, venus-G(2), or venus-E constructs, and stained for γ2. Scale, 2 µm.
Antoine Triller (142658), Claude Schweizer (142654), Hiroko Bannai (142656), Sabine Lévi (142663), Marianne Renner (142651)   +4 more
core   +1 more source