Results 61 to 70 of about 5,161 (196)

cAMP-EPAC-Dependent Regulation of Gephyrin Phosphorylation and GABAAR Trapping at Inhibitory Synapses

iScience, 2019
Summary: GABAA and glycine receptors are thought to compete for gephyrin-binding sites at mixed inhibitory synapses. Changes in the occupancy of one receptor type are therefore expected to have opposite effects on the clustering of the other receptors ...
Fumihiro Niwa, Angela Patrizio, Antoine Triller, Christian G. Specht   +3 more
doaj   +1 more source

The Molecular Architecture of Somatic Spines of the Lateral Septum

Journal of Comparative Neurology, Volume 534, Issue 9, September 2026.
Spine synapses represent stable synaptic connections that allow neurons to chemically communicate with each other. Although known for decades, the unusual spine synapses found directly on neuronal cell bodies in the lateral septum have not been characterised in detail.
Daniela Hacker, Erich Weisheim, Michaela Schweizer, Undine Schneeweiß, Maximilian Borgmeyer, Michael Brecht, Marina Mikhaylova   +6 more
wiley   +1 more source

Tuning GABAergic Inhibition: Gephyrin Molecular Organization and Functions

Neuroscience, 2020
To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise apposition to the presynaptic release sites. At inhibitory synapses, the postsynaptic protein gephyrin self-assembles to form a scaffold that anchors glycine and GABAARs to the cytoskeleton, thus ensuring the accurate accumulation of postsynaptic receptors at the ...
Pizzarelli, Rocco, Griguoli, Marilena, Zacchi, Paola, Petrini, Enrica Maria, Barberis, Andrea, Cattaneo, Antonino, Cherubini, Enrico   +6 more
openaire   +5 more sources

Regulation of Gephyrin Assembly and Glycine Receptor Synaptic Stability [PDF]

Journal of Biological Chemistry, 2006
Gephyrin is required for the formation of clusters of the glycine receptor (GlyR) in the neuronal postsynaptic membrane. It can make trimers and dimers through its N- and C-terminal G and E domains, respectively. Gephyrin oligomerization could thus create a submembrane lattice providing GlyR-binding sites.
Cécile, Bedet, Jo C, Bruusgaard, Sandra, Vergo, Line, Groth-Pedersen, Stefan, Eimer, Antoine, Triller, Christian, Vannier   +6 more
openaire   +2 more sources

Gephyrin and CYP2C9 Genetic Polymorphisms in Patients with Pharmacoresistant Epilepsy

Pharmacogenomics and Personalized Medicine, 2021
Gephyrin (GPHN) is an essential protein in the regulation of inhibitory postsynaptic density and polymorphism in the corresponding gene may have a role in the development of pharmacoresistant epilepsy (PRE). For the first time, we aimed to evaluate the association of rs928553T/C variants with PRE susceptibility.
Hamdy N El-Tallawy, Sawsan Abuhamdah, Ahmed Y Nassar, Wafaa MA Farghaly, Tahia H Saleem, Sara A Atta, Ayat A Sayed, Amal M Tohamy, Mohammed H Hassan   +8 more
openaire   +5 more sources

A zebrafish gephyrinb mutant distinguishes synaptic and enzymatic functions of Gephyrin

Neural Development
Gephyrin is thought to play a critical role in clustering glycine receptors at synapses within the central nervous system (CNS). The main in vivo evidence for this comes from Gephyrin (Gphn)-null mice, where glycine receptors are depleted from synaptic ...
Emma J. Brennan, Kelly R. Monk, Jiaxing Li   +2 more
doaj   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 196-219, September 2026.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

Subcellular localization of the DHHC-12/gephyrin interaction.

, 2014
(a) Representative image of a primary hippocampal neuron transfected with DHHC-12–HA (red) immunostained together with the Golgi-marker giantin (green). The higher magnification below shows Golgi localization of DHHC-12 in the cell body and in dendrites ...
Borislav Dejanovic (598187), Silvia Ebert (598188), Guenter Schwarz (510946), Jochen C. Meier (598189), Marcus Semtner (249048), Franziska Neuser (424593), Tobias Lamkemeyer (159366), Bernhard Lüscher (4729437)   +7 more
core   +1 more source

Chronic benzodiazepine treatment triggers gephyrin scaffold destabilization and GABAAR subsynaptic reorganization

Frontiers in Cellular Neuroscience
Benzodiazepines (BZDs) are important clinical drugs with anxiolytic, anticonvulsant, and sedative effects mediated by potentiation of inhibitory GABA type A receptors (GABAARs). Tolerance limits the clinical utility of BZDs, yet the mechanisms underlying
Caitlyn A. Chapman, Nadya Povysheva, Tyler B. Tarr, Jessica L. Nuwer, Stephen D. Meriney, Jon W. Johnson, Tija C. Jacob   +6 more
doaj   +1 more source

Key Metabolic Enzymes Underlying Astrocytic Upregulation of GABAergic Plasticity

Frontiers in Cellular Neuroscience, 2017
GABAergic plasticity is recognized as a key mechanism of shaping the activity of the neuronal networks. However, its description is challenging because of numerous neuron-specific mechanisms.
Przemysław T. Kaczor, Jerzy W. Mozrzymas, Jerzy W. Mozrzymas   +2 more
doaj   +1 more source