Results 91 to 100 of about 1,934,975 (307)

Early Enrichment Population Theory at High Redshift

The Astrophysical Journal
An early enrichment population (EEP) has been theorized to produce the observed intracluster medium (ICM) metallicity of galaxy clusters. This population likely existed at high redshifts ( z  ∼ 10), relics of which we posit exist today as dwarf galaxies.
Anne E. Blackwell, Joel N. Bregman
doaj   +1 more source

On the Mass Distribution of Stellar-Mass Black Holes

Open Astronomy, 2014
The observational stellar-mass black hole mass distribution exhibits a maximum at about 8 M⊙. It can be explained via the details of the massive star evolution, supernova explosions, or consequent black hole evolution.
Malkov O. Yu.
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The Stellar Initial Mass Function of Early Dark Matter–free Gas Objects

The Astrophysical Journal Letters
Among the remarkable strides made by JWST is the discovery of the earliest star clusters found to date. These have been proposed as early progenitors of globular clusters, which are known to come from the early stages of star formation in the Universe ...
William Lake, Michael Y. Grudić, Smadar Naoz, Naoki Yoshida, Claire E. Williams, Blakesley Burkhart, Federico Marinacci, Mark Vogelsberger, Avi Chen   +8 more
doaj   +1 more source

Do fragmentation and accretion affect the stellar initial mass function? [PDF]

, 2020
R. Riaz, D. R. G. Schleicher, S. Vanaverbeke, Ralf S. Klessen   +3 more
openalex   +1 more source

Constraining the Thin Disc Initial Mass Function using Galactic Classical Cepheids [PDF]

, 2016
Context: The Initial Mass Function (IMF) plays a crucial role on galaxy evolution and its implications on star formation theory make it a milestone for the next decade. It is in the intermediate and high mass ranges where the uncertainties of the IMF are
R. Mor, A. Robin, F. Figueras, B. L. U. D. Barcelona, Observatoire de Besanccon, A. Rechen-Institut, Heidelberg   +6 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Planet Mass Function around M Stars at 1–10 au: A Plethora of Sub-Earth Mass Objects

The Astrophysical Journal
Small planets (≲1 M _⊕ ) at intermediate orbital distances (∼1 au) represent an uncharted territory in exoplanetary science. The upcoming microlensing survey by the Nancy Grace Roman Space Telescope will be sensitive to objects as light as Ganymede and ...
Yayaati Chachan, Eve J. Lee
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source