Results 101 to 110 of about 3,405,157 (289)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

The Stellar Initial Mass Function of Early Dark Matter–free Gas Objects

open access: yesThe Astrophysical Journal Letters
Among the remarkable strides made by JWST is the discovery of the earliest star clusters found to date. These have been proposed as early progenitors of globular clusters, which are known to come from the early stages of star formation in the Universe ...
William Lake   +8 more
doaj   +1 more source

On the Mass Distribution of Stellar-Mass Black Holes

open access: yesOpen Astronomy, 2014
The observational stellar-mass black hole mass distribution exhibits a maximum at about 8 M⊙. It can be explained via the details of the massive star evolution, supernova explosions, or consequent black hole evolution.
Malkov O. Yu.
doaj   +1 more source

Measuring the stellar initial mass function

open access: yes, 2020
The birth of stars and the formation of galaxies are cornerstones of modern astrophysics. While much is known about how galaxies globally and their stars individually form and evolve, one fundamental property that affects both remains elusive. This is problematic because this key property, the stellar initial mass function (IMF), is a key tracer of the
openaire   +1 more source

The bimodal initial mass function in the Orion Nebula Cloud

open access: yes, 2016
Due to its youth, proximity and richness the Orion Nebula Cloud (ONC) is an ideal testbed to obtain a comprehensive view on the Initial Mass Function (IMF) down to the planetary mass regime.
Bayo, A.   +7 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Planet Mass Function around M Stars at 1–10 au: A Plethora of Sub-Earth Mass Objects

open access: yesThe Astrophysical Journal
Small planets (≲1 M _⊕ ) at intermediate orbital distances (∼1 au) represent an uncharted territory in exoplanetary science. The upcoming microlensing survey by the Nancy Grace Roman Space Telescope will be sensitive to objects as light as Ganymede and ...
Yayaati Chachan, Eve J. Lee
doaj   +1 more source

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