Results 101 to 110 of about 1,589,274 (291)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

The Stellar Initial Mass Function in Starburst Galaxies [PDF]

, 1999
Claus Leitherer
openalex   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

A Census of the β Pic Moving Group and Other Nearby Associations with Gaia

The Astronomical Journal
I have used the third data release of the Gaia mission to improve the reliability and completeness of membership samples in the β Pic moving group (BPMG) and other nearby associations with ages of 20–50 Myr (Sco Body, Carina, Columba, χ ^1 For, Tuc-Hor ...
K. L. Luhman
doaj   +1 more source

The Initial Mass Function of Low‐Mass Stars and Brown Dwarfs in Young Clusters [PDF]

, 2000
K. L. Luhman, G. H. Rieke, Erick T. Young, A. Cotera, H. Chen, Marcia Rieke, Glenn Schneider, Rodger I. Thompson   +7 more
openalex   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Constraining the Stellar Mass Function in the Galactic Center via Mass Loss from Stellar Collisions

Advances in Astronomy, 2011
The dense concentration of stars and high-velocity dispersions in the Galactic center imply that stellar collisions frequently occur. Stellar collisions could therefore result in significant mass loss rates.
Douglas Rubin, Abraham Loeb
doaj   +1 more source

The Initial Mass Function of a Massive Star‐forming Region W51 [PDF]

, 2000
Shin‐ichiro Okumura, Atsushi Mori, Eiji Nishihara, E. Watanabe, Takuya Yamashita   +4 more
openalex   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

The Low End of the Initial Mass Function in Young Large Magellanic Cloud Clusters. I. The Case of R136 [PDF]

, 2000
M. Sirianni, A. Nota, Claus Leitherer, Guido De Marchi, Mark Clampin   +4 more
openalex   +1 more source