Results 131 to 140 of about 1,635,352 (355)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

The Variation in the Galaxy-wide Initial Mass Function for Low-mass Stars: Modeling and Observational Insights

The Astrophysical Journal
The stellar initial mass function (IMF) characterizes the mass distribution of newly formed stars in various cosmic environments, serving as a fundamental assumption in astrophysical research. Recent findings challenge the prevalent notion of a universal
Zhiqiang Yan, Jiadong Li, Pavel Kroupa, Tereza Jerabkova, Eda Gjergo, Zhi-Yu Zhang   +5 more
doaj   +1 more source

ON THE ORIGIN OF THE SALPETER SLOPE FOR THE INITIAL MASS FUNCTION [PDF]

The Astrophysical Journal, 2011
We suggest that the intrinsic, stellar initial mass function (IMF) follows a power-law slope gamma=2, inherited from hierarchical fragmentation of molecular clouds into clumps and clumps into stars. The well-known, logarithmic Salpeter slope GAMMA=1.35 in clusters is then the aggregate slope for all the star-forming clumps contributing to an individual
openaire   +5 more sources

The SINFONI Nearby Elliptical Lens Locator Survey: discovery of two new low-redshift strong lenses and implications for the initial mass function in giant early-type galaxies [PDF]

, 2015
We present results from a blind survey to identify strong gravitational lenses among the population of low-redshift early-type galaxies. The SINFONI Nearby Elliptical Lens Locator Survey (SNELLS) uses integral-field infrared spectroscopy to search for ...
Russell J. Smith, J. Lucey, C. Conroy
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

The Present-day Mass Function of Star Clusters in the Solar Neighborhood

The Astrophysical Journal
This work analyzes the present-day mass function (PDMF) of 93 star clusters utilizing Gaia Data Release 3 data, with membership determined by the StarGo machine-learning algorithm.
Xiaoying Pang, Siqi Liao, Jiadong Li, Zhiqiang Yan, Mingjie Jian, M. B. N. Kouwenhoven, Shih-Yun Tang, Yifan Wang   +7 more
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

The Initial Mass Function of Low-mass Stars and Brown Dwarfs in the W3 Complex. [PDF]

Astron J, 2021
Huston MJ, Luhman KL.
europepmc   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Resolving the Mechanical and Radiative Feedback in J1044+0353 with Keck Cosmic Web Imager Spectral Mapping

The Astrophysical Journal
We present integral field spectroscopy toward and around J1044+0353, a rapidly growing, low-metallicity galaxy that produces extreme [O iii ] line emission.
Crystal L. Martin, Zixuan Peng, Yuan Li
doaj   +1 more source