Results 131 to 140 of about 2,106,509 (356)
Automated Multi-Material Additive Manufacturing: An Initial Exploration with Concrete
, 2022 Additive manufacturing of concrete has seen an increase of interest in recent years given its potential to revolutionize the construction industry by circumventing the geometric constraints of traditional fabrication techniques while achieving improved ...
Makinen, William
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Effect of the initial matrix material on the structure of radiation‐grafted ion‐exchange membranes: Wide‐angle and small‐angle X‐ray scattering studies [PDF]
, 2002 K. Jokela +5 more
openalex +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Materials & DesignThis study investigates the influence of billet condition and die design on the microstructure, texture evolution, and mechanical properties of extruded AA6082 flat bands.
Maria Nienaber +3 more
doaj +1 more source
The Effects of Welfare and Tax Reform: The Material Well-Being of Single Mothers in the 1980s and 1990s [PDF]
The tax and welfare programs that provide income and in-kind benefits to single mothers have changed dramatically in recent years. These changes began as far back as the mid-1980s and culminated with the 1996 welfare law that 'ended welfare as we knew it.
Bruce D. Meyer, James X. Sullivan
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, 2018 Supplemental material, 720388 for Context Matters: Contextual Factors Informing Mentoring in Art Initial Teacher Education by Ayelet Becher and Lily Orland-Barak in Journal of Teacher ...
Lily Orland-Barak (5512883) +1 more
core +1 more source