Results 141 to 150 of about 2,106,509 (356)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Students' mathematical literacy in number pattern material seen from initial mathematical abilities

Alifmatika
Mathematical literacy ability is an individual's ability to formulate, use and interpret mathematics by reasoning, and applying concepts in various contexts.
Refika Dwi Saputri, Syutaridho Syutaridho, Arvin Efriani   +2 more
doaj   +1 more source

720388sp – Supplemental material for Context Matters: Contextual Factors Informing Mentoring in Art Initial Teacher Education

, 2018
Supplemental material, 720388sp for Context Matters: Contextual Factors Informing Mentoring in Art Initial Teacher Education by Ayelet Becher and Lily Orland-Barak in Journal of Teacher ...
Lily Orland-Barak (5512883), Ayelet Becher (5512880)   +1 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Micromechanical analysis of kinematic hardening in natural clay

, 2009
This paper presents a micromechanical analysis of the macroscopic behaviour of natural clay. A microstructural stress-strain model for clayey material has been developed which considers clay as a collection of clusters.
Academy of Finland (Grant 210744) (Funder), Helsinki University of technology, , University of Massachusetts, , Academy of Finland (Grant 210744) (Funder), Karstunen, M., , University of Strathclyde, , Ecole Centrale de nates, EC MRTN-CT-2004–512120 (Funder), Yin, Zhen-Yu, , EC MRTN-CT-2004-512120 (Funder), Ecole Centrale de nates, Chang, Ching S., University of Strathclyde, Hicher, Pierre-Yves, , Helsinki University of technology, Karstunen, Minna, University of Massachusetts, Chang, Ching   +17 more
core   +1 more source

A criação de um material multimidiático para o estudo da incorporação da realidade aumentada na leitura de um poema no ciclo inicial do ensino fundamental II / Creating a multimedia material for the study of augmented reality incorporation during a poem reading in the initial cycle of middle school

, 2021
Guimarães, Rita de Fátima Rodrigues, 1971-
openalex   +1 more source

Initial Engineering and Outdoor Stability Assessment of “Gray/Black” Fullerene-Free Organic Photovoltaics Based on Only Two Complementary Absorbing Materials: A Tetrabenzotriazacorrole and a Subphthalocyanine [PDF]

, 2020
Hasan Raboui, David S. Josey, Yin Jin, Timothy P. Bender   +3 more
openalex   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Religious Schema Scale: Construction and Initial Validation of a Quantitative Measure for Religious Styles

, 2010
Streib H, Hood RW, J, Klein C. The Religious Schema Scale: Construction and Initial Validation of a Quantitative Measure for Religious Styles. International Journal for the Psychology of Religion.
Ralph W. Hood, Streib, Heinz ; https://orcid.org/, Constantin Klein, Klein, Constantin, Heinz Streib, Hood, Ralph W., Jr.   +5 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source