Results 101 to 110 of about 688,518 (313)

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

open access: yesMolecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen   +13 more
wiley   +1 more source

Processing of Space Surveillance Observations [PDF]

open access: yes
This thesis covers the processing of different types of space surveillance measurements. The emphasis is on the initial build-up of a catalogue. Most experiments focus on the identification of objects from pairs of observations by testing whether these ...
Reihs, Benedikt
core   +1 more source

A differential algebra based importance sampling method for impact probability computation on Earth resonant returns of Near Earth Objects [PDF]

open access: yes, 2018
A differential algebra based importance sampling method for uncertainty propagation and impact probability computation on the first resonant returns of Near Earth Objects is presented in this paper.
Armellin, Roberto   +3 more
core   +2 more sources

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Method of preliminary solution of the problem of space robot navigation by onboard astronomical measurements using the butterworth filter

open access: yesВестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2020
A method of preliminary solution of the problem of space robot navigation based on the results of measurements carried out using its onboard optronic equipment is presented.
V. M. Ananenko   +2 more
doaj   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

Solution of Low-Thrust Lambert Problem with Perturbative Expansions of Equinoctial Elements [PDF]

open access: yes, 2015
A method for solving the so-called low-thrust Lambert problem is proposed. After formulating it as a two-point boundary value problem, where initial and final positions are provided in terms of equinoctial variables, a first-order perturbative approach ...
AVANZINI, Giulio   +2 more
core   +1 more source

Back to the Future: Estimating Initial Globular Cluster Masses from their Present Day Stellar Mass Functions [PDF]

open access: yes, 2015
We use N-body simulations to model the 12 Gyr evolution of a suite of star clusters with identical initial stellar mass functions over a range of initial cluster masses, sizes, and orbits. Our models reproduce the distribution of present-day global stellar mass functions that is observed in the Milky Way globular cluster population.
arxiv   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

open access: yesMolecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park   +6 more
wiley   +1 more source

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