Results 111 to 120 of about 143,162 (326)

Effects of the Planar Galactic Tides and Stellar Mass on Comet Cloud Dynamics

, 2009
We report the first results of a research program to explore the sensitivity of the orbits of Oort cloud comets to changes in the strength of the Galactic tides in the plane of the disk and also to changes in the mass of the host star.
Gonzalez, Guillermo, Masi, Marco, Secco, Luigi   +2 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Orbit Determination Analysis Utilizing Radiometric and Laser Ranging Measurements for GPS Orbit [PDF]

While navigation systems for the determination of the orbit of the Global Position System (GPS) have proven to be very effective, the current issues involve lowering the error in the GPS satellite ephemerides below their current level.
Welch, Bryan W.
core   +1 more source

Probing the local dynamics of periodic orbits by the generalized alignment index (GALI) method

, 2011
As originally formulated, the Generalized Alignment Index (GALI) method of chaos detection has so far been applied to distinguish quasiperiodic from chaotic motion in conservative nonlinear dynamical systems.
Antonopoulos Ch., CH. ANTONOPOULOS, CH. SKOKOS, Christodoulidi H., Contopoulos G., Contopoulos G., Cvitanović P., Gerlach E., Hénon M., Manos T., T. MANOS   +10 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Experimental verification of possibility of spacecraft initial orbit determination using radial velocity measured by one measuring point [PDF]

, 2001
A.D. Sheptun, Oleg Ivanov, I.V. Mashtak, Yuzhnoye State Design Office, Dnipro, Ukraine, I.V. Mashtak, Yangel Yuzhnoye State Design Office, Dnipro, Ukraine   +5 more
openalex   +1 more source

The Algol triple system spatially resolved at optical wavelengths

, 2010
Interacting binaries typically have separations in the milli-arcsecond regime and hence it has been challenging to resolve them at any wavelength. However, recent advances in optical interferometry have improved our ability to discern the components in ...
Armstrong, Buscher, Csizmadia, ESA, Evans, Hartkopf, Heintz, Hill, Hummel, Kovalevsky, Labeyrie, Lindegren, Prieur, Prieur, Shepherd, Shepherd, Söderhjelm, van Moorsel   +17 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The Dynamical Environment of Dawn at Vesta

, 2012
Dawn is the first NASA mission to operate in the vicinity of the two most massive asteroids in the main belt, Ceres and Vesta. This double-rendezvous mission is enabled by the use of low-thrust solar electric propulsion. Dawn will arrive at Vesta in 2011
Britt, Consolmagno, Davis, Gaskell, Ghosh, Kaula, Keil, Konopliv, Konopliv, Konopliv, Konopliv, Lee, Lehman, M.V. Sykes, McCord, Migliorini, Miller, P. Tricarico, Pitjeva, Press, Prettyman, Rayman, Rayman, Righter, Russell, Russell, Russell, Russell, Ruzicka, Scheeres, Thomas, Thomas, Tricarico, Zellner   +33 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source