Results 161 to 170 of about 3,031,333 (292)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Improving and sustaining adolescent access to primary care in a socioeconomically vulnerable urban community in Brazil: outcomes of a quality improvement initiative. [PDF]

BMJ Paediatr Open
Timbó de Paiva Neto F, Marques RG, Saad LDC, Palacio DDC, Borella AC, Arcos AR, Miranda RM, da Silva AM, Rodrigues MDS, Vernal S.   +9 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Yellow wave: impact of a structured educational initiative on trauma education development. [PDF]

Acta Cir Bras
Kruger VF, Franqueira JV, Fraga AMA, Calderan TRA, Trindade JVC, Fraga GP.   +5 more
europepmc   +1 more source

Analyzing the Poverty Impact of the Enhanced Heavily Indebted Poor Countries (HIPC) Initiative in Bolivia [PDF]

The purpose of this article is to analyse the impact of debt relief programs on poverty reduction in Bolivia by focusing on the enhanced HIPC initiative.
Heylen, Fanny Heylen
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Correction: Youth focused life skills training and counselling services program-An inter-sectoral initiative in India: Program development and preliminary analysis of factors affecting life skills. [PDF]

PLoS One
Sukumar GM, Banandur PS, Nagaraja SR, Shenoy AB, Shahane S, Shankar RG, Banavaram AA, Yekkar GS, Rajneesh S, Gopalkrishna G.   +9 more
europepmc   +1 more source

Russian initiative initiatives (Initiative, Enterprising, Smecticism)

, 2017
S.S. Neustroev, V.A. Predybailo, A.I. Galkina, E.A. Burnasheva, I.A. Grishan   +4 more
openaire   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

The Cardiac Rehabilitation Referral Improvement in a Safety-Net Population (CRISP) Initiative. [PDF]

JACC Case Rep
Burke M, Gan A, Jinno S, Ge B, Balasubramanian S, Zern E, Chen G, Gordon SS.   +7 more
europepmc   +1 more source