Results 101 to 110 of about 3,538,607 (285)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Frontiers in PharmacologyBackgroundIntracerebral haemorrhage (ICH) is the deadliest subtype of stroke. Surgery remains a vital measure for life-saving in emergency situations, however, the recovery of post-operative patients is not optimistic.
Yanbo Song +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Sıcak ve Soğuk Yolluk Sistemlerinin Karşılaştırılması
Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2015 Plastik sektörü dünyada çok hızlı gelişen sektörlerin başında gelmektedir. Bu teknolojik gelişmeler ışığında hacim kalıplarında plastiklerin şekillendirilmesinde sıcak yolluk sisteminin önemini gittikçe arttırmıştır. Sıcak yolluk sisteminin önemli ölçüde
Turğut ÖZTÜRK, Arif ÖZKAN
doaj
Granular gases under extreme driving
, 2010 We study inelastic gases in two dimensions using event-driven molecular dynamics simulations. Our focus is the nature of the stationary state attained by rare injection of large amounts of energy to balance the dissipation due to collisions. We find that
Brilliantov N. +6 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Patient Preference and Adherence, 2019 David L Gandell,1 E Jay Bienen,2 Jennifer Gudeman3 1Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA; 2The Curry Rockefeller Group, Tarrytown, NY, USA; 3Medical Affairs, AMAG Pharmaceuticals Inc., Waltham, MA, USA ...
Gandell DL, Bienen EJ, Gudeman J
doaj
İstanbul Medical JournalIntroduction: The primary aim of this study was to determine the ultrasound (US)-guided therapies for musculoskeletal pain during pregnancy. The secondary aim of the study was to define the parameters associated with treatment outcomes.
Suna Aşkın Turan +4 more
doaj +1 more source
Geometry of Power Flows and Optimization in Distribution Networks
, 2013 We investigate the geometry of injection regions and its relationship to optimization of power flows in tree networks. The injection region is the set of all vectors of bus power injections that satisfy the network and operation constraints.
Lavaei, Javad, Tse, David, Zhang, Baosen
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source