Results 91 to 100 of about 2,025,323 (287)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Numerical Modeling of Variable Fluid Injection-Rate Modes on Fracturing Network Evolution in Naturally Fractured Formations

Energies, 2016
In this study, variable injection-rate technology was numerically investigated in a pre-existing discrete fracture network (DFN) formation, the Tarim Basin in China.
Yu Wang, Xiao Li, Bo Zhang
doaj   +1 more source

How does a Secular Instability Grow in a Hyperaccretion Flow?

, 2015
Hyperaccretion flows with mass accretion rates far above the Eddington rate have an N-shaped equilibrium curve on the $\Sigma$-$\dot{M}$ plane (with $\Sigma$ and $\dot{M}$ being surface density and mass accretion rate, respectively).
Kawanaka, Norita, Kimura, Mariko, Mineshige, Shin   +2 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Numerical Simulation of the Simultaneous Development of Multiple Fractures in Horizontal Wells Based on the Extended Finite Element Method

Energies
Simultaneous multiple-fracture treatments in horizontal wellbores have become an essential technology for the economic development of shale gas reservoirs. During hydraulic fracturing, fracture initiation and propagation always induce additional stresses
Enshun Ping, Peng Zhao, Haiyan Zhu, Yuzhong Wang, Zixi Jiao, Qingjie Zhao, Gan Feng   +6 more
doaj   +1 more source

Injection Rate Interval in Fluctuation Section of Curtain Grouting in Pumped Storage Projects [PDF]

长江科学院院报
[Objective] Curtain grouting is a commonly used method for anti-seepage reinforcement in pumped storage projects, and injection rate is an important monitoring parameter that directly affects grouting quality. The fluctuation section of injection rate is
LIU Jie-yuan, ZHANG Fan, ZHAN Cheng-yuan, HE Ji, LIU Quan, ZHANG Hong-wei
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effect of Liquid Injection Arrangements on Injection Flow Rate of a Laboratory-Scale Venturi Scrubber

Frontiers in Energy Research, 2019
As the core device of a filtered containment venting system (FCVS), Venturi Scrubber is an efficient device to scrub the radioactive gases and aerosols before release into the atmosphere.
Guangzong Zheng, Guangzong Zheng, Bo Chen, Jishen Li, Kaiyi Shi, Haifeng Gu   +5 more
doaj   +1 more source

A calculation method and experiment study of high-pressure common rail injection rate with solenoid injectors. [PDF]

Sci Prog, 2021
Gao Z, Li G, Xu C, Li H, Wang M.
europepmc   +1 more source