Results 81 to 90 of about 15,316,992 (300)

Investigation on an Injection Strategy Optimization for Diesel Engines Using a One-Dimensional Spray Model

Energies, 2019
Common rail systems have been widely used in diesel engines due to the stricter emission regulations. The advances in injector technology and ultrahigh injection pressure greatly promote the development of multiple-injection strategy, leading to the ...
Intarat Naruemon, Long Liu, Qihao Mei, Xiuzhen Ma   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Effect of fuel injection rate shapes on mixture formation and combustion characteristic in a free-piston diesel engine generator

, 2018
The free-piston engine generator is a new power machinery, which removes the crank-shaft mechanism. This article aims to study the impact of different injection rate shapes (left triangle, rectangle, and right triangle) on the free-piston engine ...
Cuijie Han, Chenheng Yuan, Yituan He, Yang Liu   +3 more
semanticscholar   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Numerical Simulation of the Simultaneous Development of Multiple Fractures in Horizontal Wells Based on the Extended Finite Element Method

Energies
Simultaneous multiple-fracture treatments in horizontal wellbores have become an essential technology for the economic development of shale gas reservoirs. During hydraulic fracturing, fracture initiation and propagation always induce additional stresses
Enshun Ping, Peng Zhao, Haiyan Zhu, Yuzhong Wang, Zixi Jiao, Qingjie Zhao, Gan Feng   +6 more
doaj   +1 more source

Numerical Modeling of Variable Fluid Injection-Rate Modes on Fracturing Network Evolution in Naturally Fractured Formations

Energies, 2016
In this study, variable injection-rate technology was numerically investigated in a pre-existing discrete fracture network (DFN) formation, the Tarim Basin in China.
Yu Wang, Xiao Li, Bo Zhang
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Injection Rate Interval in Fluctuation Section of Curtain Grouting in Pumped Storage Projects [PDF]

长江科学院院报
[Objective] Curtain grouting is a commonly used method for anti-seepage reinforcement in pumped storage projects, and injection rate is an important monitoring parameter that directly affects grouting quality. The fluctuation section of injection rate is
LIU Jie-yuan, ZHANG Fan, ZHAN Cheng-yuan, HE Ji, LIU Quan, ZHANG Hong-wei
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Study on profile control ability of polymer microspheres to heterogeneous formation

Youqicang pingjia yu kaifa, 2019
The morphology and rheological properties of polymer microspheres PM1 were evaluated by optical microscope and rheometer. The effects of injection rate and concentration of microsphere system on the migration and plugging properties in porous media as ...
ZHAO Shuai, PU Wanfen, LI Kexing, YANG Yang   +3 more
doaj