Results 121 to 130 of about 300,512 (305)

Fructose improves titanium dioxide nanoparticles induced alterations in developmental competence of mouse oocytes

BMC Veterinary Research
Aims We investigated the effects of intraperitoneal injections of titanium dioxide nanoparticles (TiO2 NPs, 100 mg/kg) for 5 consecutive days on the developmental competence of murine oocytes. Furthermore, study the effects of TiO2 NPs on antioxidant and
Mohammed A Elmetwally, Amal Helmy, Ahmed Balboula, Mohamed Eladl, Basma Hamed, Samah Lashen, Shaymaa Rezk, Amira Yaseen, Heba Sharawy, Mamdouh Hussien, Samy Zabel, Abdelmonem Montaser, Amal Halawa   +12 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

GCase activity in mice receiving diltiazem by intraperitoneal injection:

, 2013
The 9H mice were given diltiazem by intraperitoneal injections at 50, 100 or 200 mg/kg/d for 7 days. GCase activity increased by ∼1.2 fold in the brain of D409H mice at each of the three doses, i.e., the response was not dose dependent.
Gregory A. Grabowski (353044), Ying Sun (23237), Brian Quinn (353037), Huimin Ran (353034), Benjamin Liou (353035), You-Hai Xu (364882)   +5 more
core   +1 more source

Optimal Experimental Design for System Identification in a Bi-Hormonal Intraperitoneal Artificial Pancreas [PDF]

For individuals with diabetes, the intraperitoneal drug-delivery route may enable fully automated artificial pancreas technology. For such systems, the model predictive control (MPC) algorithm is favorable.
Bengtsson, Henrik, Davari Benam, Karim, Engell, Sarah Ellinor, Jørgensen, John Bagterp, Benam, Karim Davari, Fougner, Anders Lyngvi, Jorgensen, John Bagterp   +6 more
core   +1 more source

Evaluation of the Immunosafety of Cucurbit[n]uril In Vivo

Pharmaceutics
Cucurbiturils are a family of macrocyclic oligomers capable of forming host–guest complexes with various molecules. Due to noncovalent binding to drug molecules and low toxicity, cucurbiturils has been extensively investigated as potential carriers for ...
Ekaterina Pashkina, Alina Aktanova, Olga Boeva, Maria Bykova, Elena Gavrilova, Elena Goiman, Ekaterina Kovalenko, Na’il Saleh, Lyubov Grishina, Vladimir Kozlov   +9 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Errors in the technique of intraperitoneal injection of mice [PDF]

Applied Microbiology, 1968
J P, Steward, E P, Ornellas, K D, Beernink, W H, Northway   +3 more
openaire   +2 more sources

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

THE PATHOLOGY OF INTRAPERITONEAL BILE INJECTIONS IN THE RABBIT [PDF]

Journal of Experimental Medicine, 1911
C H, Bunting, W H, Brown
openaire   +2 more sources