Results 61 to 70 of about 120,047 (307)

Effects of sodium lactate injection on meat quality and lactate content in broiler chickens: emphasis on injection method and dosage

Poultry Science
: This study aims to develop an experimental model of high lactate levels in broilers to mimic the condition of birds under stress or diseases and evaluate its consequent effects on meat quality.
Zhenxin Wang, Lin Zhang, Tong Xing, Liang Zhao, Feng Gao   +4 more
doaj   +1 more source

Post Mortem Study on the Effects of Routine Handling and Manipulation of Laboratory Mice

Animals, 2022
Routine handling and manipulation of laboratory mice are integral components of most preclinical studies. Any type of handling and manipulation may cause stress and result in physical harm to mice, potentially leading to unintended consequences of ...
Charles-Antoine Assenmacher, Matthew Lanza, James C Tarrant, Kristin L Gardiner, Eric Blankemeyer, Enrico Radaelli   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Inhibition of HDAC6 alleviating lipopolysaccharide-induced p38MAPK phosphorylation and neuroinflammation in mice

Pharmaceutical Biology, 2019
Context: Researchers in a variety of fields have extensively focused on histone deacetylase 6 (HDAC6) due to its aggravation of inflammatory reaction.
Yuanjian Song, Li Qin, Rongli Yang, Fan Yang, Nwobodo Alexander Kenechukwu, Xiaofang Zhao, Xiaoyan Zhou, Xiangru Wen, Lei Li   +8 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Bile acids promote lipopolysaccharide clearance via the hepato-biliary pathway in broiler chickens

Ecotoxicology and Environmental Safety
Lipopolysaccharide (LPS) acts as a trigger that disrupts metabolic functions and the immune system. While bile acids (BA) have detoxification and anti-inflammatory effects, their role in promoting LPS excretion in broiler chickens remains unclear.
Liang Chen, Shuai Ma, Aizhi Cao, Ruqian Zhao   +3 more
doaj   +1 more source

Cecum location in rats and the implications for intraperitoneal injections [PDF]

Lab Animal, 2007
Intraperitoneal injection is a common route for parenteral administration of drugs in rodents. A serious consequence associated with this technique, however, is the puncture of vital organs such as the cecum, which causes pain and occasionally peritonitis.
Genaro A, Coria-Avila, Alex M, Gavrila, Shann, Ménard, Nafissa, Ismail, James G, Pfaus   +4 more
openaire   +2 more sources

Optimal Experimental Design for System Identification in a Bi-Hormonal Intraperitoneal Artificial Pancreas [PDF]

For individuals with diabetes, the intraperitoneal drug-delivery route may enable fully automated artificial pancreas technology. For such systems, the model predictive control (MPC) algorithm is favorable.
Bengtsson, Henrik, Davari Benam, Karim, Engell, Sarah Ellinor, Jørgensen, John Bagterp, Benam, Karim Davari, Fougner, Anders Lyngvi, Jorgensen, John Bagterp   +6 more
core   +1 more source