Results 81 to 90 of about 120,047 (307)

Differential effects of insulin injections and insulin infusions on levels of glycogen in rat adipose tissue

, 2004
Studies have shown that while injections of insulin cause an increase in fat mass, infusions of insulin increase fat mass. The aim of this paper was to test the hypothesis that if an increase in glycogen is an indicator of an impending increase in ...
Antwi, D. A.
core   +1 more source

Genipin‐Crosslinked, Silane‐Anchored 3D Tumor–Stroma Microtissues for High‐Content On‐Chip Drug Testing

Advanced Healthcare Materials, EarlyView.
We describe a microfluidic tumor‐stroma co‐culture model, engineered to resist collagen‐hydrogel contraction driven by fibroblast activity. Surface silanization with APTES covalently anchors the matrix to the chip, while Genipin crosslinking progressively increases stiffness and elasticity without harming cells. This supports >10 days of co‐culture and
Doriane Le Manach, Reza Kowsari‐Esfahan, Emilia Reszczyńska, Philippe Nghe, Matthias Nees   +4 more
wiley   +1 more source

Chitosan Oligosaccharides Attenuate Ocular Inflammation in Rats with Experimental Autoimmune Anterior Uveitis

Mediators of Inflammation, 2014
We investigated the protective effects and mechanisms of chitosan oligosaccharides (COS) on experimental autoimmune anterior uveitis (EAAU) in rats. EAAU was induced in Lewis rats by footpad and intraperitoneal injections of melanin-associated antigen ...
I-Mo Fang, Chang-Hao Yang, Chung-May Yang   +2 more
doaj   +1 more source

The effects of intramuscular and intraperitoneal injections of benzo(a)pyrene on selected biomarkers in Clarias gariepinus. [PDF]

, 2011
This study investigated the dose-dependent and time-course effects of intramuscular (i.m.) and intraperitoneal (i.p.) injection of benzo[a]pyrene (BaP) on the biomarkers EROD activity, GST activity, concentrations of BaP metabolites in bile, and visceral
Zamri Ishak, Ishak, Zamri, Mohd Arif Syed, Syed, Mohd Arif, Simon Charles Courtenay, Christianus, Annie, Annie Christianus, Ali Karami, Courtenay, Simon Charles, Varnamkhasti, Ali Karami   +9 more
core   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Effects of intraperitoneal injections of saline on the alcohol and sucrose consumption of C57/BL10 mice

, 2002
RATIONALE: To determine the effects of multiple saline injections on alcohol drinking by male and female C57/BL10 mice with low preference for alcohol.OBJECTIVE: An investigation of the effects of multiple saline injections on alcohol consumption, with a
O'Callaghan, M J, Croft, A P; id_orcid, Little, H J   +2 more
core   +1 more source

Neutrophil‐Mimetic MRI Enables Ultra‐Early Detection of Vascular Inflammation After Stroke

Advanced Healthcare Materials, EarlyView.
In this study, we developed neutrophil‐mimetic MRI probes that detect ultra‐early neuroinflammation following ischemic stroke by targeting E‐selectin. Within seconds of their injection, these microparticles mimic initial leukocyte adhesion to the activated cerebral endothelium.
Marion Isabelle Morvan, Damien Levard, Eloïse Lemarchand, Amal Boublay, Charly Helaine, Jolan Malherbe, Mikaël Naveau, Didier Goux, Igor Khalin, Ankita Talukdar, Cheun Pelleter, Charlène Jacqmarcq, Erwan Baudron, Isabelle Bardou, Sara Martinez de Lizarrondo, Maxime Gauberti, Denis Vivien, Antoine Philippe Fournier   +17 more
wiley   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Therapeutic efficacy of Diadema setosum extract against DMH-induced colon cancer in adult male albino rats

Bulletin of Pharmaceutical Sciences. Assiut University
Background: Globally, colorectal cancer (CRC) is an important contributor to cancer-associated disease and mortality. The objective of this study was to assess the antitumor potential of Diadema setosum extract (DE) against 1,2-dimethylhydrazine (DMH ...
Mahmoud Ashry
doaj   +1 more source

Systemic Delivery of NELL-1 through Intraperitoneal Route for the Reversal of Osteoporosis in OVX-Mice [PDF]

, 2017
Bone health can be jeopardized by diseases such as osteoporosis, or by special environmental conditions like microgravity. Both conditions result in reduced bone mineral density (BMD) and an increased risk of bone fractures.
Mohammad, Abdulaziz
core