Results 71 to 80 of about 300,512 (305)

Intraperitoneal Glucose Transport to Micrometastasis: A Multimodal In Vivo Imaging Investigation in a Mouse Lymphoma Model

, 2021
Bc-DLFL.1 is a novel spontaneous, high-grade transplantable mouse B-cell lymphoma model for selective serosal propagation. These cells attach to the omentum and mesentery and show dissemination in mesenteric lymph nodes. We aimed to investigate its early
Nikolett Hegedűs, Erzsébet Schmidt, Katalin Zámbó, Dániel Dezső, Hussain Alizadeh, David Tuch, Zsombor Ritter, Dávid Szöllősi, Xinkai Jia, Péter Balogh, Ildikó Horváth, Domokos Máthé, Kunal Vyas   +12 more
core   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Effect of repeated intraperitoneal injections of different concentrations of oxycodone on immune function in mice [PDF]

BackgroundThe effect of oxycodone as an opioid receptor agonist on immune function is still controversial. In this study, we investigated the possible effects of oxycodone on immune function in mice and its possible mechanisms of action.MethodsBy ...
Jingjing Liu, Shaoqiang Huang, Sumeng Chen   +2 more
core   +1 more source

Transient plasma injections in the dayside magnetosphere: One-to-one correlated observations by cluster and by SuperDARN [PDF]

, 2004
Conjunctions in the cusp between the four Cluster spacecraft and SuperDARN ground-based radars offer unique opportunities to compare the signatures of transient plasma injections simultaneously in the high-altitude dayside magnetosphere and in the ...
Laakso, H., J.-M. Bosqued, Förster, M., Foerster, M., H. Laakso (7591349), Fontaine, D., Cerisier, J. C., J.-C. Cerisier, A. Marchaudon (7650635), Fontaine, Dominique, J. A. Wild (7591442), Bosqued, J.-M., Décréau, Pierrette, P. M. E. Décréau (7651646), Dunlop, M., Wild, J., M. W. Dunlop, Bosqued, J., Bosqued, J. M., Marchaudon, A., Dunlop, M. W., Cerisier, J., A. Marchaudon, P. M. E. Décréau, M. W. Dunlop (7591493), H. Laakso, Marchaudon, Aurélie, Wild, J. A., J. A. Wild, Décréau, P. M. E., J.-M. Bosqued (7685081), D. Fontaine, M. Förster, Décréau, P., M. Förster (2934723), J.-C. Cerisier (7685078), D. Fontaine (7685084), Cerisier, J.-C.   +37 more
core   +3 more sources

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

On the compound Poisson risk model with periodic capital injections [PDF]

, 2018
The analysis of capital injection strategy in the literature of insurance risk models (e.g. Pafumi, 1998; Dickson and Waters, 2004) typically assumes that whenever the surplus becomes negative, the amount of shortfall is injected so that the company can ...
Cheung, ECK ; https://orcid.org/, Yang, H, Cheung, ECK, Zhang, Z   +3 more
core   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Neutralization of Tumor Necrosis Factor Bioactivity Ameliorates Urethane-Induced Pulmonary Oncogenesis in Mice

Neoplasia: An International Journal for Oncology Research, 2011
Tumor necrosis factor (TNF) has been implicated in inflammation-associated tumor progression. Although multiple reports identified a role for TNF signaling in established cancers, few studies have assessed the impact of TNF blockade on early tumor ...
Sophia P. Karabela, Chrysoula A. Kairi, Sophia Magkouta, Ioannis Psallidas, Charalampos Moschos, Ioannis Stathopoulos, Spyros G. Zakynthinos, Charis Roussos, Ioannis Kalomenidis, Georgios T. Stathopoulos   +9 more
doaj   +1 more source

Zwitterionic Polymer Coating Enabled Chronic Dopamine Sensing and Electrophysiology Recording in Free‐Moving Mice

Advanced Healthcare Materials, EarlyView.
Application of a zwitterionic poly(sulfobetaine methacrylate) (PSB) coating to microelectrode arrays and Ag/AgCl reference electrodes effectively inhibits biofouling and structural degradation. This strategy successfully enables simultaneous, long‐term electrophysiological recording and dopamine sensing in freely behaving mice, facilitating ...
Bingchen Wu, Cort Thompson, Thomas Deakin, Yan Xu, Colleen A. McClung, Xinyan Tracy Cui   +5 more
wiley   +1 more source

Ameliorative Effects of Tribulus Terrestris (Qutayb) Extracts Against Gentamicin-Induced Nephrotoxicity in Wistar Rats

International Journal of Nephrology
Tribulus terrestris has a long-standing historical legacy, having been used for centuries in the treatment of various kidney disorders and other health issues.
Ahmed Al-Mohamadi, Imadeldin M. Taj Eldin, Doa’a Ibrahim, Rowaida Albadani   +3 more
doaj   +1 more source