Results 41 to 50 of about 2,309,665 (315)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Exploring Intra-Articular Administration of Monoclonal Antibodies as a Novel Approach to Osteoarthritis Treatment: A Systematic Review

Biomedicines
Biological drugs, including monoclonal antibodies, represent a revolutionary strategy in all fields of medicine, offering promising results even in the treatment of osteoarthritis (OA).
Amarildo Smakaj, Elena Gasbarra, Tommaso Cardelli, Chiara Salvati, Roberto Bonanni, Ida Cariati, Riccardo Iundusi, Umberto Tarantino   +7 more
doaj   +1 more source

The Effect of the Ventrogluteal Injection Training on the Knowledge Levels and Preferences of Health Professionals

Forbes Tıp Dergisi, 2020
INTRODUCTION: This study is aimed to determine the effect of ventrogluteal injection training on the health professionals' knowledge levels and preferences about the use of the ventroglu- teal region for intramuscular injections.
Ahu Çırlak, Nur Temiz, Merve Başol
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Ultrasound-Assisted Lumbar Interlaminar Epidural Dye Injection and Evaluation of Its Distribution by Anatomical Dissection

Frontiers in Medicine, 2019
Background: Epidural steroid injections are frequently used to treat lumbar radicular pain. However, the spread of a solute in the epidural space needs further elucidation.
Irina Evansa, Irina Evansa, Angelika Krumina, Anna Simonova, Viktorija Dzabijeva, Svetlana Fedorovica, Alla Hadunkina, Alla Hadunkina, Natalja Zlobina, Grigorijs Vabels, Eva Strike, Ludmila Viksna, Indulis Vanags   +12 more
doaj   +1 more source

Treatment of degenerative chronic low back pain with fluoroscopically guided epidural procaine-corticosteroid injection [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Low back pain is one of the most common painful conditions in the modern age. Therefore, it is very important to establish the most effective protocol for the treatment of this condition.
Ćulafić Slobodan, Stefanović Dara, Dulović Dragan, Minić Ljubodrag, Ćulafić Andrijana   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer-controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study [PDF]

Vojnosanitetski Pregled, 2019
Bacground/Aim. The efficient dental anesthesia, which is related to the clinically adequate depth, duration and the width of anesthetic field, is an important prerequisite for successful dental treatment.
Ćetković Dejan, Milić Marija S., Biočanin Vladimir, Brajić Ivana, Ćalasan Dejan, Radović Katarina, Živković Rade, Brković Božidar   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Intra-mesenteric steroids for steroid-refractory graft-versus-host disease in pediatric patients: A safe option

Biomédica: revista del Instituto Nacional de Salud
Introduction. Graft-versus-host disease is a serious complication after hematopoietic stem cell transplantation and is a major cause of death post-transplantation.
Ana M. Aristizábal, Lina P. Montaña, Jaiber Gutiérrez, Diego Medina, Alexis A. Franco, Eliana Manzi, Ángela Devia Zapata, Walter Mosquera   +7 more
doaj   +1 more source