Results 61 to 70 of about 1,365,673 (335)
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Octreotide in the therapy of recurrent medulloblastomas [PDF]
Archive of Oncology, 2006 BACKGROUND: Recurrence of medulloblastoma appears after 30% to 40% of the surgeries. Different from primary medulloblastoma, in which five-year survival rate is 50%, the survival time of relapses much shorter and only 20% of the patients manage to ...
Stefanović Ivan +3 more
doaj +1 more source
Applied Categorical Structures, 2017 In a locally $ $-presentable category, with $ $ a regular cardinal, classes of objects that are injective with respect to a family of morphisms whose domains and codomains are $ $-presentable, are known to be characterized by their closure under products, $ $-directed colimits and $ $-pure subobjects. Replacing the strict commutativity of diagrams
J. Rosický, W. Tholen
openaire +2 more sources
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Injections and Patient Satisfaction in Zulu-Speaking Patients
South African Family Practice, 2002 One of the main objectives in a consultation is for patients to leave the consulting room feeling satisfied with their consultation. Satisfied patients are more likely to remain with a physician, keep appointments, comply with treatment and refer other ...
H.F. Niebuhr, M.J. Whitfield
doaj +1 more source
Subconjunctival delivery of p75NTR antagonists reduces the inflammatory, vascular, and neurodegenerative pathologies of diabetic retinopathy [PDF]
, 2017 The p75NTR is a novel therapeutic target validated in a streptozotocin mouse model of diabetic retinopathy. Intravitreal (IVT) injection of small molecule p75NTR antagonist THX-B was therapeutic and resolved the inflammatory, vascular, and ...
Barcelona, Pablo Federico +5 more
core +1 more source
Injective and non-injective realizations with symmetry
Contributions to Discrete Mathematics, 2008 Contributions to Discrete Mathematics, Vol 5, No 1 (2010)
openaire +3 more sources
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
FEBS Letters, EarlyView.To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche +2 more
wiley +1 more source
MACROECONOMIC ASPECTS OF SUSTAINABLE DEVELOPMENT OF THE ECONOMY
Вестник университета, 2019 The essence and indicators of a concept of sustainable development of economy have been considered. Dynamics of an indicator of social and economic development of the region (gross regional product) has been analyzed and the stability indicator has been ...
S. A. Bakhodurova
doaj +1 more source