Results 81 to 90 of about 1,365,673 (335)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Insulin Injections Promote the Growth of Aberrant Crypt Foci in the Colon of Rats [PDF]

, 1997
The main objective of the present study was to test the hypothesis that exogenous insulin would enhance colon carcinogenesis. Thirty-six female F344 rats, fed ad libitum a low fat rodent chow, received a single azoxymethane injection (20 mg/kg), and were
Corpet, Denis E., Jacquinet, Claire, Peiffer, Ginette, Taché, Sylviane   +3 more
core   +1 more source

The formation of regular interarm magnetic fields in spiral galaxies

, 2015
Observations of regular magnetic fields in several nearby galaxies reveal magnetic arms situated between the material arms. The nature of these magnetic arms is a topic of active debate.
Beck, Rainer, Krause, Marita, Moss, David, Sokoloff, Dmitri, Stepanov, Rodion   +4 more
core   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Jovian Injections Observed at High Latitude

Geophysical Research Letters, 2019
The polar orbit of Juno at Jupiter provides a unique opportunity to observe high‐latitude energetic particle injections. We measure energy‐dispersed impulsive injections of protons and electrons. Ion injection signatures are just as prevalent as electron
D. K. Haggerty, B. H. Mauk, C. P. Paranicas, G. Clark, P. Kollmann, A. M. Rymer, G. R. Gladstone, T. K. Greathouse, S. J. Bolton, S. M. Levin   +9 more
doaj   +1 more source

STABILITY-INDICATING LC METHOD FOR THE QUANTIFICATION OF MIDAZOLAM ACTIVE PHARMACEUTICAL INGREDIENT AND IN PHARMACEUTICAL FORMULATIONS

Drug Analytical Research, 2018
A stability-indicating LC method was validated for the quantification of midazolam (MDZ) active pharmaceutical ingredient (API) and in pharmaceutical formulations. Isocratic chromatography was performed on C18 column with mobile phase containing methanol/
Daiane Anzilaggo, Bádila Regina Dalla Costa, Luciana Grazziotin Rossato-Grando, Hellen Karine Stulzer, Charise Dallazem Bertol   +4 more
doaj   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Exploring Intra-Articular Administration of Monoclonal Antibodies as a Novel Approach to Osteoarthritis Treatment: A Systematic Review

Biomedicines
Biological drugs, including monoclonal antibodies, represent a revolutionary strategy in all fields of medicine, offering promising results even in the treatment of osteoarthritis (OA).
Amarildo Smakaj, Elena Gasbarra, Tommaso Cardelli, Chiara Salvati, Roberto Bonanni, Ida Cariati, Riccardo Iundusi, Umberto Tarantino   +7 more
doaj   +1 more source

Perception of upper lip augmentation utilizing simulated photography

Archives of Plastic Surgery, 2019
Background No head to head comparison is available between surgical lip lifting and upper lip filler injections to decide which technique yields the best results in patients.
Gary Linkov, Elizabeth Wick, Dorina Kallogjeri, Collin L. Chen, Gregory H. Branham   +4 more
doaj   +1 more source

A stereotaxic method for small animals using experimentally determined reference profiles [PDF]

, 1986
In bats conventional stereotaxic methods do not yield sufficient positional accuracy to allow reliable recordings and tracer injections in subnuclei of the auditory system. In a newly developed stereotaxic system experimentally measured patterns of skull
Andres, Bock, Bures, De Valois, Gerd Schuller, Horsley, Matthäus Betz, Susanne Radtke-Schuller   +7 more
core   +1 more source