Results 21 to 30 of about 20,209,781 (300)

Fish Granzyme A Shows a Greater Role Than Granzyme B in Fish Innate Cell-Mediated Cytotoxicity

Frontiers in Immunology, 2019
Granzymes (Gzm) are serine proteases, contained into the secretory granules of cytotoxic cells, responsible for the cell-mediated cytotoxicity (CMC) against tumor cells and intracellular pathogens such as virus and bacteria.
Elena Chaves-Pozo, Yulema Valero, Yulema Valero, Maria Teresa Lozano, Pablo Rodríguez-Cerezo, Liang Miao, Vittorio Campo, Maria Angeles Esteban, Alberto Cuesta   +8 more
doaj   +1 more source

Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners?

Frontiers in Aging Neuroscience, 2021
Innate immune system activation and inflammation are associated with and may contribute to clinical outcomes in people with Down syndrome (DS), neurodegenerative diseases such as Alzheimer’s disease (AD), and normal aging.
Md. Mahiuddin Ahmed, Md. Mahiuddin Ahmed, Md. Mahiuddin Ahmed, Noah R. Johnson, Noah R. Johnson, Noah R. Johnson, Timothy D. Boyd, Timothy D. Boyd, Timothy D. Boyd, Christina Coughlan, Christina Coughlan, Christina Coughlan, Heidi J. Chial, Heidi J. Chial, Heidi J. Chial, Huntington Potter, Huntington Potter, Huntington Potter   +17 more
doaj   +1 more source

Curating the innate immunity interactome [PDF]

, 2010
peer-reviewedBackground: The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks.
Laird, Matthew R, Anastasia Sribnaia, Winsor, Geoffrey L., Lynn, David J, Giselle Ring, Foroushani, Amir K., Laird, Matthew R., Que, Jaimmie, Geoffrey L Winsor, Robert EW Hancock, Sribnaia, Anastasia, Hancock, Robert E.W., Ring, Giselle, Melissa Yau, Fiona SL Brinkman, Calvin Chan, Jaimmie Que, David J Lynn, Brinkman, Fiona S. L., Naseer, Misbah, Matthew R Laird, Yau, Melissa, Lo, Raymond, Raymond Lo, Chan, Calvin, Wee, Kathleen, Winsor, Geoffrey L, Breuer, Karin, Kathleen Wee, Amir K Foroushani, Hancock, R. E. W. (Robert E. W.), Brinkman, Fiona S., Misbah Naseer, Karin Breuer, Lynn, David J., Hancock, Robert E W, Foroushani, Amir K, Brinkman, Fiona S L   +37 more
core   +1 more source

Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion

Frontiers in Microbiology, 2021
Hepatitis viruses are primary causative agents of hepatitis and represent a major source of public health problems in the world. The host innate immune system forms the first line of defense against hepatitis viruses.
Chonghui Xu, Chonghui Xu, Jizheng Chen, Jizheng Chen, Xinwen Chen, Xinwen Chen   +5 more
doaj   +1 more source

Fish Peroxiredoxins and Their Role in Immunity

Biology, 2015
Peroxiredoxins (Prxs) are a family of antioxidant enzymes that protect cells from oxidative damage. In addition, Prxs may act as modulators of inflammation, protect against cell death and tumour progression, and facilitate tissue repair after damage. The
Yulema Valero, Francisco J. Martínez-Morcillo, M. Ángeles Esteban, Elena Chaves-Pozo, Alberto Cuesta   +4 more
doaj   +1 more source

The Role of the Immune System in the Pathophysiology of Essential Hypertension

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2022
Hypertension (HTN) is a critical worldwide health issue and an imperative risk factor for the development of cardiovascular disease and kidney disease. There are many crevices in our knowledge about the pathophysiology of HTN.
Mahsa Rekabi, Zahra Daneshmandi, Elham Sadati, Mahsa Mirzendehdel, Seyed Alireza Mahdaviani, Ali Valinejadi, Ali Akbar Velayati, Parisa Honarpisheh   +7 more
doaj   +1 more source

Effects of the Dietary Tryptophan and Aspartate on the Immune Response of Meagre (Argyrosomus regius) after Stress

Fishes, 2018
Stress is one of the main problems of farmed fish, where it has been seen to result in a variety of disorders and negative effects. It is considered very important to minimize such effects and one option is the use of dietary additives.
Daniel Gonzalez-Silvera, Marcelino Herrera, Inmaculada Giráldez, María Ángeles Esteban   +3 more
doaj   +1 more source

Chitin modulates innate immune responses of keratinocytes. [PDF]

, 2011
Chitin, after cellulose the second most abundant polysaccharide in nature, is an essential component of exoskeletons of crabs, shrimps and insects and protects these organisms from harsh conditions in their environment.
Korting, Hans Christian, Koller, Barbara, Thomas Ruzicka, Korting Hans Christian, Rupec Rudolph, Müller-Wiefel Alisa Sophie, Alisa Sophie Müller-Wiefel, Müller-Wiefel, Alisa Sophie, Rudolph Rupec, Koller Barbara, Hans Christian Korting, Ruzicka, Thomas, Barbara Koller, Ruzicka Thomas, Rupec, Rudolph   +14 more
core   +2 more sources

The Evasion of Antiviral Innate Immunity by Chicken DNA Viruses

Frontiers in Microbiology, 2021
The innate immune system constitutes the first line of host defense. Viruses have evolved multiple mechanisms to escape host immune surveillance, which has been explored extensively for human DNA viruses. There is growing evidence showing the interaction
Li Gao, Shijun Zheng, Yongqiang Wang
doaj   +1 more source

Aging of the innate immune system [PDF]

Current Opinion in Immunology, 2010
The innate immune system is composed of a network of cells including neutrophils, NK and NKT cells, monocytes/macrophages, and dendritic cells that mediate the earliest interactions with pathogens. Age-associated defects are observed in the activation of all of these cell types, linked to compromised signal transduction pathways including the Toll-like
Albert C, Shaw, Samit, Joshi, Hannah, Greenwood, Alexander, Panda, Janet M, Lord   +4 more
openaire   +2 more sources