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TLRs and chronic inflammation [PDF]
International Journal of Biochemistry and Cell Biology, 2010 After the discovery of Toll-like receptors (TLRs), innate immune mechanisms came back in the focus of scientific research. With more and more mechanisms of TLR biology known, it has become clear that these and also other innate immune receptors are not only of crucial importance in the immune response to invading pathogens, but also play a role in the ...
Steffen Gay, Caroline Ospelt
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Of Flies and Men—The Discovery of TLRs
Cells, 2022 In 2011, the Nobel Prize in Physiology or Medicine was awarded to three immunologists: Bruce A. Beutler, Jules A. Hoffmann, and Ralph M. Steinman. While Steinman was honored for his work on dendritic cells and adaptive immunity, Beutler and Hoffman received the prize for their contributions to discoveries in innate immunity. In 1996, Hoffmann found the
Hauke Weiss
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Toll-like receptors and their role in the pathogenesis of myasthenia gravis: a comprehensive review [PDF]
Frontiers in ImmunologyMyasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder marked by autoantibody-mediated dysfunction at the neuromuscular junction, resulting in fluctuating muscle weakness. The pathogenesis of MG involves a complex interplay between genetic
Xiaoxiao Zheng +5 more
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Seminars in Immunology, 2006 The Toll-like receptor (TLR) family plays an instructive role in innate immune responses against microbial pathogens, as well as the subsequent induction of adaptive immune responses. TLRs recognize specific molecular patterns found in a broad range of microbial pathogens such as bacteria and viruses, triggering inflammatory and antiviral responses and
Taro, Kawai, Shizuo, Akira
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Recent advances in cancer immunotherapy: Modulation of tumor microenvironment by Toll-like receptor ligands [PDF]
BioImpacts, 2022 Immunotherapy is considered a promising approach for cancer treatment. An important strategy for cancer immunotherapy is the use of cancer vaccines, which have been widely used for cancer treatment.
Leila Rostamizadeh +6 more
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Toll-Like Receptor 4 (TLR4) and AMPK Relevance in Cardiovascular Disease [PDF]
Advanced Pharmaceutical Bulletin, 2023 Toll-like receptors (TLRs) are essential receptors of the innate immune system, playing a significant role in cardiovascular diseases. TLR4, with the highest expression among TLRs in the heart, has been investigated extensively for its critical role in ...
Haleh Vaez +3 more
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Evaluation of Toll-like receptors expression in terms of colon cancer
Исследования и практика в медицине, 2022 Purpose of the study. To evaluate the number of cells with the CD45+/- phenotype expressing Toll-like receptors (TLRs) in tissues of the tumor, peritumoral area and resection line tissues in colon cancer (CC) with various tumor locations.Materials and ...
E. A. Dzhenkova +13 more
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RELATIONSHIP BETWEEN THE INNATE AND ADAPTIVE IMMUNITY IN INFECTIONS (REVISION OF CLASSIC DOGMA)
Инфекция и иммунитет, 2014 . The mechanisms of the immune system responding to an infection depend on a complex interrelation between the elements of innate and adaptive immunity. The current understanding of how signaling from innate immunity receptors shapes the adaptive immune ...
I. S. Freidlin
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Role of Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems
Frontiers in Immunology, 2021 Toll-like receptors (TLRs) are a class of proteins playing a key role in innate and adaptive immune responses. TLRs are involved in the development and progression of neuroimmune diseases via initiating inflammatory responses.
Haixia Li +9 more
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Brazilian Journal of Veterinary Pathology, 2011 Malaria is caused by protozoan parasites of the genus Plasmodium, which is transmitted by Anopheline mosquitoes. Experimental murine models using rodent malaria are useful for studying pathologic aspects of severe malaria.
Ana Patrícia C. Silva +4 more
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