Results 1 to 10 of about 148,110 (341)
TLRs and chronic inflammation [PDF]
International Journal of Biochemistry and Cell Biology, 2010 After the discovery of Toll-like receptors (TLRs), innate immune mechanisms came back in the focus of scientific research. With more and more mechanisms of TLR biology known, it has become clear that these and also other innate immune receptors are not only of crucial importance in the immune response to invading pathogens, but also play a role in the ...
Steffen Gay, Caroline Ospelt
exaly +8 more sources
Life Sciences, 2019 Toll-like receptors (TLRs) comprise a clan of proteins involved in identification and triggering a suitable response against pathogenic attacks. As lung is steadily exposed to multiple infectious agents, antigens and host-derived danger signals, the ...
Shaniya Ahmad, Anant Mohan, Kapil Dev
exaly +4 more sources
Toll-like receptor (TLRs) agonists and antagonists for COVID-19 treatments
Frontiers in Pharmacology, 2022 Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) rapidly infects humans and animals which make coronavirus disease 2019 (COVID-19) a grievous epidemic worldwide which broke out in 2020. According to data analysis of the other coronavirus
Ming-Hui Yang, Kun Yu, Shou-Long Deng
exaly +2 more sources
Toll-Like Receptors (TLRs), NOD-Like Receptors (NLRs), and RIG-I-Like Receptors (RLRs) in Innate Immunity. TLRs, NLRs, and RLRs Ligands as Immunotherapeutic Agents for Hematopoietic Diseases [PDF]
International Journal of Molecular Sciences, 2021 The innate immune system plays a pivotal role in the first line of host defense against infections and is equipped with patterns recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular ...
K. Wicherska-Pawłowska +2 more
semanticscholar +2 more sources
International Journal of Molecular Sciences, 2020 While platelet function has traditionally been described in the context of maintaining vascular integrity, recent evidence suggests that platelets can modulate inflammation in a much more sophisticated and nuanced manner than previously thought.
Fabrice Cognasse +2 more
exaly +2 more sources
Toll-like receptors and their role in the pathogenesis of myasthenia gravis: a comprehensive review [PDF]
Frontiers in ImmunologyMyasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder marked by autoantibody-mediated dysfunction at the neuromuscular junction, resulting in fluctuating muscle weakness. The pathogenesis of MG involves a complex interplay between genetic
Xiaoxiao Zheng +5 more
doaj +2 more sources
Blood, 2009 AbstractOne of the most fundamental questions in immunology pertains to the recognition of non-self, which for the most part means microbes. How do we initially realize that we have been inoculated with microbes, and how is the immune response ignited?
B. Beutler
semanticscholar +4 more sources
Systematic review of structural and immunological features of mollusk toll-like receptors in aquaculture context [PDF]
Frontiers in ImmunologyIntroductionToll-like receptors (TLRs) are transmembrane proteins essential for innate immunity. While vertebrate TLRs have been well studied, knowledge of their distribution, structure, and function in mollusks remains limited, despite their importance ...
Hongyu Li +10 more
doaj +2 more sources
Seminars in Immunology, 2006 Mammalian Toll-like receptors (TLRs) play a critical role in detection of invading pathogens as well as triggering of subsequent inflammatory and immune responses. Each TLR recognizes distinct microbial components and activates different signaling pathways by selective utilization of adaptor molecules.
Taro, Kawai, Shizuo, Akira
openaire +5 more sources
Toll-Like Receptor 4 (TLR4) and AMPK Relevance in Cardiovascular Disease [PDF]
Advanced Pharmaceutical Bulletin, 2023 Toll-like receptors (TLRs) are essential receptors of the innate immune system, playing a significant role in cardiovascular diseases. TLR4, with the highest expression among TLRs in the heart, has been investigated extensively for its critical role in ...
Haleh Vaez +3 more
doaj +1 more source