Results 11 to 20 of about 95,151 (305)

TLRs in Hepatic Cellular Crosstalk [PDF]

Gastroenterology Research and Practice, 2010
Toll-like receptors (TLRs) are expressed on all major subsets of liver cells. Both exogenous ligands derived from pathogens, and endogenous ligands that are products of cellular injury, engage these receptors and activate aspects of innate immunity ...
Amelie E. Bigorgne, Ian Nicholas Crispe
doaj   +2 more sources

Synthetic Toll-Like Receptors for Control of Innate Immunity With Far-Red Light. [PDF]

Adv Sci (Weinh)
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Leopold AV, Verkhusha VV.
europepmc   +2 more sources

The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCs) - Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2 [PDF]

, 2001
Toll-like receptors (TLRs) have been found to be key elements in pathogen recognition by the host immune system. Dendritic cells (DCs) are crucial for both innate immune responses and initiation of acquired immunity.
Dimmeler, S, Ralf R. Schumann, Michelsen, KS, Michelsen, K.S., Kirschning, C.J., Kathrin S. Michelsen, Alexandra Aicher, Mariette Mohaupt, Aicher, A, Aicher, A., Thomas Hartung, Stefanie Dimmeler, Hartung, T., Dimmeler, S., Schumann, R.R., Mohaupt, M, Kirschning, CJ, Mohaupt, M., Carsten J. Kirschning, Hartung, T, Schumann, RR   +20 more
core   +1 more source

Sox4 represses host innate immunity to facilitate pathogen infection by hijacking the TLR signaling networks

Virulence, 2021
Toll-like receptors (TLRs) are essential for the protection of the host from pathogen infections by initiating the integration of contextual cues to regulate inflammation and immunity.
Jian Shang, Yuan Zheng, Jiayin Mo, Wenbiao Wang, Zhen Luo, Yongkui Li, Xulin Chen, Qiwei Zhang, Kailang Wu, Weiyong Liu, Jianguo Wu   +10 more
doaj   +1 more source

Role of Microglia TLRs in Neurodegeneration [PDF]

, 2018
Toll-like receptors (TLRs) are a group of receptors widely distributed in the organism. In the central nervous system, they are expressed in neurons, astrocytes and microglia.
Carla Ribeiro Alvares Batista, Fiebich, Bernd L., Antonio Carlos Pinheiro de Oliveira, Yousif, Nizar M., Soraya Wilke Saliba, Ribeiro Alvares Batista, Carla, Saliba, Soraya Wilke, Nizar M. Yousif, Bernd L. Fiebich, Oliveira, Antônio Carlos Pinheiro de   +9 more
core   +2 more sources

Two non-mammalian toll-like receptors (TLR21 and TLR22) from golden pompano (Trachinotus ovatus): Molecular cloning, gene characterization and expression analysis

Aquaculture Reports, 2021
Toll-like receptors (TLRs), important pattern recognition receptors (PRRs), involve in recognizing pathogen-associated molecular patterns (PAMPs) and play crucial roles in the host innate immunity.
Shuangshuang Gao, Teng Xu, Ruifeng Qiao, Jianchao Lu, Yang Xu, Shu Hu, Youchuan Wei, Zhitao Qi   +7 more
doaj   +1 more source

Toll-like receptors as a part of osteoarthritis pathophysiology: anti-inflammatory, analgesic and neuroprotective effects

Неврология, нейропсихиатрия, психосоматика, 2021
Toll-like receptors (TLRs) act as receptors for bacterial lipopolysaccharides (LPS) and participate in innate immunity. Excessive TLRs activity leads to chronic inflammation and the development of several comorbid pathologies, including osteoarthritis ...
I. Yu. Torshin, O. A. Gromova, A. M. Lila, L. I. Alekseeva, E. A. Taskina   +4 more
doaj   +1 more source

Of mice and men: Interaction of Corynebacterium diphtheriae strains with murine and human phagocytes

Virulence, 2019
Seven non-toxigenic C. diphtheriae strains and one toxigenic strain were analyzed with regard to their interaction with murine macrophages (BMM) and human THP-1 macrophage-like cells. Proliferation assays with BMM and THP-1 revealed similar intracellular
Dulanthi Weerasekera, Tamara Fastner, Roland Lang, Andreas Burkovski, Lisa Ott   +4 more
doaj   +1 more source

Toll-Like Receptors -2, -3, -4 and -7 Expression Patterns in the Liver of a CLP-Induced Sepsis Mouse Model

Journal of Investigative Surgery, 2020
Objective: To investigate the expression of toll-like receptors (TLRs) in the liver of septic mouse model. Materials and methods: For this study seventy-two C57BL/6J mice were utilized.
Chrysostomos V. Aravanis, Alkistis Kapelouzou, Stylianos Vagios, Diamantis I. Tsilimigras, Michalis Katsimpoulas, Demetrios Moris, Theano D. Demesticha, Dimitrios Schizas, Alkiviadis Kostakis, Anastasios Machairas, Theodore Liakakos   +10 more
doaj   +1 more source

LIGAND INDUCED CHEMOTAXIS OF MACROPHAGE CELL LINE U937

Медицинская иммунология, 2014
Treatment of malignant tumors is among challenging issues of clinical medicine. Dissemination and matestasis of tumor cells plays a major role in oncology, being immediately dependent on chemotaxis of tumor cells.
A. B. Filina, O. A. Svitich, L. V. Gankovskaya, P. A. Labzhinov, T. M. Parfenova, V. V. Zverev   +5 more
doaj   +1 more source