Results 11 to 20 of about 148,110 (341)
TLRs: Innate Immune Sentries against SARS-CoV-2 Infection [PDF]
International Journal of Molecular Sciences, 2023 Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March 2020.
S. Mantovani +4 more
semanticscholar +3 more sources
Role of Microglia TLRs in Neurodegeneration [PDF]
Frontiers in Cellular Neuroscience, 2018 Toll-like receptors (TLRs) are a group of receptors widely distributed in the organism. In the central nervous system, they are expressed in neurons, astrocytes and microglia.
B. Fiebich +4 more
semanticscholar +5 more sources
The Role of Toll-like Receptors (TLRs) Mediated Inflammation in Pancreatic Cancer Pathophysiology [PDF]
International Journal of Molecular Sciences, 2021 Pancreatic cancer (PC) is one of the most lethal forms of cancer, characterized by its aggressiveness and metastatic potential. Despite significant improvements in PC treatment and management, the complexity of the molecular pathways underlying its ...
Arturo Orlacchio, P. Mazzone
semanticscholar +2 more sources
TLRs in Hepatic Cellular Crosstalk [PDF]
Gastroenterology Research and Practice, 2010 Toll-like receptors (TLRs) are expressed on all major subsets of liver cells. Both exogenous ligands derived from pathogens, and endogenous ligands that are products of cellular injury, engage these receptors and activate aspects of innate immunity ...
Amelie E. Bigorgne, Ian Nicholas Crispe
doaj +2 more sources
Release from Unc93b1 reinforces the compartmentalized activation of select TLRs [PDF]
Nature, 2019 Nucleic acid-sensing Toll-like receptors (TLRs) are subject to complex regulation to facilitate the recognition of microbial DNA and RNA while limiting the recognition of an organism’s own nucleic acids1.
Olivia Majer +5 more
semanticscholar +3 more sources
The role of TLRs in cervical cancer with HPV infection: a review [PDF]
Signal Transduction and Targeted Therapy, 2017 The main cause of cervical cancer is persistent infection with high-risk human papilloma virus (HR-HPV), but not all human papilloma virus (HPV) infections lead to cervical cancer. The key factors that determine the outcome of HPV infection remain poorly
Xiao Yang, Yanxiang Cheng, Chunsheng Li
semanticscholar +2 more sources
Recent advances in cancer immunotherapy: Modulation of tumor microenvironment by Toll-like receptor ligands [PDF]
BioImpacts, 2022 Immunotherapy is considered a promising approach for cancer treatment. An important strategy for cancer immunotherapy is the use of cancer vaccines, which have been widely used for cancer treatment.
Leila Rostamizadeh +6 more
doaj +1 more source
Application of toll-like receptors (TLRs) and their agonists in cancer vaccines and immunotherapy
Frontiers in Immunology, 2023 Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) expressed in various immune cell types and perform multiple purposes and duties involved in the induction of innate and adaptive immunity.
Samik Chakraborty +6 more
semanticscholar +1 more source
BioMed Research International, 2021 Toll-like receptors (TLRs) are the important mediators of inflammatory pathways in the gut which play a major role in mediating the immune responses towards a wide variety of pathogen-derived ligands and link adaptive immunity with the innate immunity ...
A. Sameer, S. Nissar
semanticscholar +1 more source
Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson’s Disease
Frontiers in Immunology, 2021 According to emerging studies, the excessive activation of microglia and the subsequent release of pro-inflammatory cytokines play important roles in the pathogenesis and progression of Parkinson’s disease (PD).
Yunna Li +11 more
semanticscholar +1 more source