Results 21 to 30 of about 95,151 (305)

The Association Between Gut Microbiota, Toll-Like Receptors, and Colorectal Cancer

Clinical Medicine Insights: Oncology, 2022
The large number of microbes found in the gut are involved in various critical biological processes in the human body and have dynamic and complex interactions with the immune system.
Yongkun Fang, Cheng Yan, Qi Zhao, Bin Zhao, Yiqun Liao, Yuji Chen, Daorong Wang, Dong Tang   +7 more
doaj   +1 more source

STUDYING THE ROLE OF GENES POLYMORPHISM OF CYTOKINES AND TOLL-LIKE RECEPTORS IN PYODERMA PATHOGENESIS

Известия высших учебных заведений. Поволжский регион: Медицинские науки, 2020
Background. At present many authors associate pathogenesis with the defect in genes polymorphism of key cytokines and the genes defect of Toll-like receptors (TLRs) of congenital immune system.
N. I. Baranova, N. Yu. Alekseeva, N. I. Mikulyak   +2 more
doaj   +1 more source

DEF Cell-Derived Exosomal miR-148a-5p Promotes DTMUV Replication by Negative Regulating TLR3 Expression

Viruses, 2020
Duck tembusu virus (DTMUV) is a single-stranded, positive-polarity RNA flavivirus that has caused considerable economic losses in China in recent years.
Hongyan Guo, Anchun Cheng, Xingcui Zhang, YuHong Pan, Mingshu Wang, Juan Huang, Dekang Zhu, Shun Chen, Mafeng Liu, Xinxin Zhao, Ying Wu, Qiao Yang, Shaqiu Zhang, Yanling Yu, Leichang Pan, Bin Tian, Mujeeb Ur Rehman, Xiaoyue Chen, Yunya Liu, Ling Zhang, Zhongqiong Yin, Bo Jing, Renyong Jia   +22 more
doaj   +1 more source

The Role of Toll Like Receptors in Pregnancy [PDF]

International Journal of Fertility and Sterility, 2013
For many years, the innate immunity was of less interest than the adaptive immunity because it was perceived to have secondary importance in the functionality of the immune system.
Elham Amirchaghmaghi, Seyed Abdolvahab Taghavi, Farnaz Shapouri, Shaghayegh Saeidi, Abbas Rezaei, Reza Aflatoonian   +5 more
doaj  

TLRs of Our Fathers [PDF]

Immunity, 2016
Two new studies published in The American Journal of Human Genetics (Dannemann et al., 2016; Deschamps et al., 2016) show that introgression of innate immune genes from Neandertals and Denisovans contributed to the modern genome of European and Asian, but not African, populations, and this might partly explain differences in susceptibility to immune ...
Netea, M.G., Joosten, L.A.B.
openaire   +3 more sources

When the allergy alarm bells toll: The role of Toll-like receptors in allergic diseases and treatment

Frontiers in Molecular Biosciences, 2023
Toll-like receptors of the human immune system are specialized pathogen detectors able to link innate and adaptive immune responses. TLR ligands include among others bacteria-, mycoplasma- or virus-derived compounds such as lipids, lipo- and ...
Mario Wenger, Sophie Grosse-Kathoefer, Amin Kraiem, Erica Pelamatti, Natalia Nunes, Lisa Pointner, Lorenz Aglas   +6 more
doaj   +1 more source

Messenger RNA expression of toll-like receptors (TLR2, TLR4, and TLR9) in HIV-1 infected patients with and without tuberculosis co-infection

International Journal of Mycobacteriology, 2022
Background: Gene expression levels of TLRs (TLR2, TLR4 and TLR9) are directly involved in the virus recognition and initiation of innate immune responses, therefore, the effect of HIV infection on TLRs gene expression was investigated in functional ...
Gaurav Kaushik, Richa Vashishtha
doaj   +1 more source

Toll-Like Receptors Serve as Biomarkers for Early Diagnosis and Prognosis Assessment of Kidney Renal Clear Cell Carcinoma by Influencing the Immune Microenvironment: Comprehensive Bioinformatics Analysis Combined With Experimental Validation

Frontiers in Molecular Biosciences, 2022
Background: Toll-like receptors (TLRs) are important initiators of innate and acquired immune responses. However, its role in kidney renal clear cell carcinoma (KIRC) remains unclear.Methods: TLRs and their relationships with KIRC were studied in detail ...
Xiong Zou, Xiong Zou, Xiong Zou, Xiong Zou, Bingqian Guo, Bingqian Guo, Bingqian Guo, Bingqian Guo, Qiang Ling, Qiang Ling, Qiang Ling, Qiang Ling, Zengnan Mo, Zengnan Mo, Zengnan Mo, Zengnan Mo, Zengnan Mo   +16 more
doaj   +1 more source

New DiaP277 analogue shifts DCs to tolerogenic, and modulates NF-Kβ1 to suppress autoreactive T lymphocytes in the type 1 diabetic mice

Autoimmunity, 2018
Therapeutic efficacy of P277 against type 1 diabetes was extensively investigated and clinically evidenced. Clinical trials Phases I and II concluded promising results, while the data of P277 immunogenicity in Phase III trials represented weak responses ...
Murad Alahdal, Jing Liangliang, Lu Shiping, Xing Yun, Huashan Gao, Zhou Jialei, Waseem Hassan, Liang Jin, Cao Rongyue   +8 more
doaj   +1 more source

The role of epithelial cells in atopy pathogenesis

Бюллетень сибирской медицины, 2019
Aim. The study of the mechanisms of atopic disease formation and a model of immunopathogenesis of the atopic diseases.Methods. Determination of surface lymphocytes receptors in peripheral blood of atopic bronchial asthma and atopic dermatitis patients ...
A. N. Kazimirsky, J. M. Salmasi, G. V. Poryadin, O. A. Svitich, B. G. Bragvadze, A. A. Alekseeva, L. V. Gankovskaya   +6 more
doaj   +1 more source