Results 71 to 80 of about 20,209,781 (300)

Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System [PDF]

, 2018
Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in
Mohsen, Mona Omar Mahmoud, Ariane C. Gomes, Vogel, Monique, Monique Vogel, Bachmann, Martin, Martin F. Bachmann, Martin Bachmann, Mohsen, Mona O, Gomes, Ariane C, Mona O. Mohsen, Mona Mohsen, Martin F. Bachmann, Mona O. Mohsen, Ariane Gomes, Ariane C. Gomes, Gomes AC, Bachmann MF, Mohsen MO, Vogel M   +18 more
core   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Fetal Lymphoid Organ Immune Responses to Transient and Persistent Infection with Bovine Viral Diarrhea Virus

Viruses, 2020
Bovine Viral Diarrhea Virus (BVDV) fetal infections occur in two forms; persistent infection (PI) or transient infection (TI), depending on what stage of gestation the fetus is infected.
Katie J. Knapek, Hanah M. Georges, Hana Van Campen, Jeanette V. Bishop, Helle Bielefeldt-Ohmann, Natalia P. Smirnova, Thomas R. Hansen   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Regulation of the innate immune response in rheumatoid arthritis

Frontiers in Immunology
Rheumatoid arthritis (RA) is a common inflammatory joint disorder characterized by progressive joint destruction, leading to painful deformity and limited mobility, for which there is currently no effective cure.
Aikeremujiang Muheremu, Aikeremujiang Muheremu, Shalayiding Aierxiding, Shalayiding Aierxiding, Jian Gao, Jian Gao   +5 more
doaj   +1 more source

Hygiene hypothesis and innate immunity. evaluating the role of environmental factors and genetic polymorphisms on the expression of receptors of the innate immune system [PDF]

, 2009
Background In ‘westernised’ countries, the prevalence of childhood asthma and allergy has risen throughout the last few decades. A series of epidemiological studies showed reduced prevalence of asthma and allergy among farmers’ children compared to non ...
Bieli, Christian
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

lncRNAs Regulate Innate Immune Responses and Their Roles in Macrophage Polarization

Mediators of Inflammation, 2018
The innate immune system is the first line of defense against microbial pathogens. The activated innate immune system plays important roles in eliciting antimicrobial defenses.
Zhen Wang, Ying Zheng
doaj   +1 more source

Systems integration of innate and adaptive immunity [PDF]

Vaccine, 2015
The pathogens causing AIDS, malaria, and tuberculosis have proven too complex to be overcome by classical approaches to vaccination. The complexities of human immunology and pathogen-induced modulation of the immune system mandate new approaches to vaccine discovery and design.
Daniel E. Zak, Alan Aderem
openaire   +2 more sources

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Rocha-Ferreira, E, Eridan Rocha-Ferreira, Eridan eRocha-Ferreira, Mariya eHristova, Hristova, M, Mariya Hristova   +5 more
core   +1 more source