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Innate Immunity in the Mucosal Immune System

Current Pharmaceutical Design, 2006
The mucosal immune system is equipped with unique innate and acquired defense mechanisms which provide a first line of protection against ingested and inhaled infectious agents. Peyer's patches (PPs) and nasopharynx-associated lymphoid tissue (NALT) have been shown to be important inductive sites for the initiation of the acquired phase of antigen ...
Tomonori, Nochi, Hiroshi, Kiyono
openaire   +2 more sources

Innate Immunity in Systemic Sclerosis

Current Rheumatology Reports, 2017
Systemic sclerosis (SSc) is a heterogeneous autoimmune disease which has defined three hallmarks: Small vessel vasculopathy, production of autoantibodies and fibroblast dysfunction. The exact aetiology of the disease remains unknown, due to the complex nature of the cellular signalling pathways involved. However, there is strong and consistent evidence
Christopher, Dowson   +3 more
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Control of Adaptive Immunity by the Innate Immune System [PDF]

open access: yesNature Immunology, 2015
Microbial infections are recognized by the innate immune system both to elicit immediate defense and to generate long-lasting adaptive immunity. To detect and respond to vastly different groups of pathogens, the innate immune system uses several recognition systems that rely on sensing common structural and functional features associated with different
Ruslan Medzhitov, Akiko Iwasaki
exaly   +3 more sources

Adaptation in the innate immune system and heterologous innate immunity

Cellular and Molecular Life Sciences, 2014
The innate immune system recognizes deviation from homeostasis caused by infectious or non-infectious assaults. The threshold for its activation seems to be established by a calibration process that includes sensing of microbial molecular patterns from commensal bacteria and of endogenous signals.
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