Results 231 to 240 of about 19,688,530 (256)

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Harnessing the innate immune system by revolutionizing macrophage-mediated cancer immunotherapy. [PDF]

J Biosci
Reghu G, Vemula PK, Bhat SG, Narayanan S.   +3 more
europepmc   +1 more source

Systemic Innate Immune System Restoration as a Therapeutic Approach for Neurodegenerative Disease: Effects of NP001 on Amyotrophic Lateral Sclerosis (ALS) Progression. [PDF]

Biomedicines
McGrath MS, Zhang R, Bracci PM, Azhir A, Forrest BD.   +4 more
europepmc   +1 more source

Modelling molecular differences in the innate immune system responses of chickens and ducks to highly pathogenic avian influenza virus

Wood T, An G, Bryant CE, Ferguson BJ.
europepmc   +1 more source

Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System [PDF]

Vaccines, 2018
Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in
Ariane C Gomes, Mona O Mohsen, Martin F. Bachmann   +2 more
exaly   +3 more sources

The porcine innate immune system: An update [PDF]

Developmental and Comparative Immunology, 2014
Over the last few years, we have seen an increasing interest and demand for pigs in biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of their anatomy, genetics, and physiology, and often are the model of ...
Artur Summerfield, Alex Pasternak, Tobias Kaeser   +2 more
exaly   +2 more sources

Balancing the innate immune system in tumor development [PDF]

Trends in Cell Biology, 2015
Cells of the innate immune system have a dual role in cancer development in both tumor initiation and progression. Innate immune cells can, on the one hand, aid malignant transformation and tumor outgrowth and, on the other hand, prevent tumor ...
Catharina Hagerling, Zena Werb
exaly   +2 more sources

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COVID-19 and the human innate immune system

Cell, 2021
Anna C. Aschenbrenner, Joachim Schultze
exaly