Results 191 to 200 of about 1,083,097 (291)

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

NOD1 and NOD2: Essential Monitoring Partners in the Innate Immune System. [PDF]

Curr Issues Mol Biol
Li Z, Shang D.
europepmc   +1 more source

Role of the innate immune system in host defence against bacterial infections: focus on the Toll‐like receptors [PDF]

, 2007
Barbara Albiger, Sofia Dahlberg, Birgitta Henriques‐Normark, Staffan Normark   +3 more
openalex   +1 more source

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

Predicting viral proteins that evade the innate immune system: a machine learning-based immunoinformatics tool. [PDF]

BMC Bioinformatics
Beltrán JF, Belén LH, Yáñez AJ, Jimenez L.   +3 more
europepmc   +1 more source

Editorial: The innate immune system in rheumatoid arthritis. [PDF]

Front Immunol, 2022
Chen Z, Leceta J, Abdul-Sater AA, Delgado M.   +3 more
europepmc   +1 more source

Effects of Low Concentrations of Arsenic on the Innate Immune System of the Zebrafish (Danio Rerio) [PDF]

, 2007
A. S. Nayak, Christopher Lage, Carol H. Kim   +2 more
openalex   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

The Liver X Receptor Promotes Immune Homeostasis via Controlled Activation of the Innate Immune System in the Liver. [PDF]

Biomolecules
Nakashima H, Kearney BM, Kinoshita M.
europepmc   +1 more source

Obesity Correlates with Chronic Inflammation of the Innate Immune System in Preeclampsia and HELLP Syndrome during Pregnancy. [PDF]

Biomedicines, 2023
Rimboeck J, Gruber M, Weigl M, Huber P, Lunz D, Petermichl W.   +5 more
europepmc   +1 more source