Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche+16 more
wiley +1 more source
Brucella requires a functional Type IV secretion system to elicit innate immune responses in mice [PDF]
Christelle M. Roux+6 more
openalex +1 more source
Predicting viral proteins that evade the innate immune system: a machine learning-based immunoinformatics tool. [PDF]
Beltrán JF+3 more
europepmc +1 more source
On the path to predicting immune responses in the lung: Modeling the pulmonary innate immune system at the air-liquid interface (ALI). [PDF]
Graf J+4 more
europepmc +1 more source
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
S. Gasser+3 more
semanticscholar +1 more source
BX‐001N, a polyethylene glycol‐conjugated bilirubin 3α nanoparticle, is the first GMP‐grade, synthetic bilirubin‐based nanomedicine. It effectively attenuates acute renal injury, facilitates subacute renal recovery, and suppresses chronic fibrosis after renal ischemia/reperfusion injury via anti‐oxidant and immune‐modulating activity.
Ji‐Jing Yan+13 more
wiley +1 more source
InnateDB: facilitating systems‐level analyses of the mammalian innate immune response [PDF]
David J. Lynn+22 more
openalex +1 more source
The Liver X Receptor Promotes Immune Homeostasis via Controlled Activation of the Innate Immune System in the Liver. [PDF]
Nakashima H, Kearney BM, Kinoshita M.
europepmc +1 more source
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto+2 more
wiley +1 more source
The impact of trauma relevant concentrations of prostaglandin E2 on the anti-microbial activity of the innate immune system. [PDF]
Nicholson T+3 more
europepmc +1 more source