Results 101 to 110 of about 18,668,522 (300)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Octopaminergic Signaling Mediates Neural Regulation of Innate Immunity in Caenorhabditis elegans

mBio, 2018
Upon pathogen infection, the nervous system regulates innate immunity to confer coordinated protection to the host. However, the precise mechanisms of such regulation remain unclear.
Durai Sellegounder, Chung-Hsiang Yuan, Phillip Wibisono, Yiyong Liu, Jingru Sun   +4 more
doaj   +1 more source

Systems integration of innate and adaptive immunity [PDF]

Vaccine, 2015
The pathogens causing AIDS, malaria, and tuberculosis have proven too complex to be overcome by classical approaches to vaccination. The complexities of human immunology and pathogen-induced modulation of the immune system mandate new approaches to vaccine discovery and design.
Daniel E. Zak, Alan Aderem
openaire   +2 more sources

Innate immunity against HIV: a priority target for HIV prevention research. [PDF]

, 2010
This review summarizes recent advances and current gaps in understanding of innate immunity to human immunodeficiency virus (HIV) infection, and identifies key scientific priorities to enable application of this knowledge to the development of novel ...
PAXTON W, ROMARIS M, LINDBLAD E, DONCEL G, BORROW P, Persephone Borrow, Borrow, P, LEHNER T, DE MAGISTRIS MT, Shattock, Robin J., MEDAGLINI, DONATA, Vyakarnam, Annapurna, PATTERSON S, Annapurna Vyakarnam, POLI G, EUROPRISE WORKING GROUP BOGERS W, KIRCHHOFF F, KELLY C, TOWERS G, SILVESTRI G, DEBRE P, Robin J Shattock, Shattock, RJ, SHATTOCK RJ, Vyakarnam Annapurna, Borrow, Persephone, Borrow Persephone, GOODIER M, null null, SPECK R, EUROPRISE Working Group, GEIJTENBEEK T, Vyakarnam, A, Shattock Robin J, WAGNER H., VYAKARNAM A   +35 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A strong immune response in young adult honeybees masks their increased susceptibility to infection compared to older bees [PDF]

, 2012
Honeybees, Apis mellifera, show age-related division of labor in which young adults perform maintenance ("housekeeping") tasks inside the colony before switching to outside foraging at approximately 23 days old. Disease resistance is an important feature
Baxter, LA, James C Bull, Bull James C., Ryabov, EV, Laura A. Baxter, Baxter Laura A., Mead, A, Pell, JK, Judith K. Pell (107694), Laura A Baxter, Osborne Juliet L., Ryabov, Eugene V., Chandler, D, Prince Gill, Judith K. Pell¤b, Juliet L Osborne, Prince, G, Osborne, Juliet L., Osborne, JL, Judith K Pell, Cunjin Zhang, Prince, Gillian, Dave Chandler (107700), Zhang, C., Laura A. Baxter (107691), Ryabov, E. V., Zhang Cunjin, Dave Ch, Chandler Dave, Baxter, L. A., Juliet L. Osborne¤c, James C. Bull (107677), Pell Judith K., Ryabov Eugene V., Baxter, Laura, James Bull, Chandler, Dave, Eugene V. Ryabov (107680), Mead, A. (Andrew), Zhang, Cunjin, Eugene V Ryabov, Andrew Mead, Cunjin Zhang (107690), James C. Bull, Mead Andrew, Chandler, D., Gill Prince, Bull, James C., Prince, G., Pell, Judith K., Dave Chandler, Pell, J. K., Osborne, J. L., Juliet L. Osborne (107697), Zhang, C, Andrew Mead (107686), Mead, A., Bull, JC, Bull, J. C., Eugene V. Ryabov, Gill Prince (107683)   +60 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response [PDF]

, 2012
Background: Leishmania (L.) species are the causative agent of leishmaniasis. Due to the lack of efficient vaccine candidates, drug therapies are the only option to deal with cutaneous leishmaniasis.
Uwe Ritter (130470), Schmid, Maximilian, Hanses Frank, Ulrike Schleicher (104689), Frank Hanses, Maximilian Schmid, Florian, Christian, Frank Hanses (148604), Zimara Nicole, Wolfgang Ernst (13060), Wege, Anja Kathrin, Anja Kathrin Wege, Anja Kathrin Wege (148586), Christian Florian, Ernst, Wolfgang, Uwe Ritter, Hanses, Frank, Maximilian Schmid (148609), Florian Christian, Ritter Uwe, Nicole Zimara (148595), Zimara, Nicole, Christian Florian (148590), Schleicher, Ulrike, Ritter, Uwe, Nicole Zimara, Ernst Wolfgang, Schmid Maximilian, Schleicher Ulrike, Wege Anja Kathrin, Wolfgang Ernst, Ulrike Schleicher   +31 more
core   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

hUCMSCs Mitigate LPS-Induced Trained Immunity in Ischemic Stroke

Frontiers in Immunology, 2020
Innate immune memory is a part of the innate immune system that facilitates the elimination of pathogens. However, it may exacerbate neuropathology. In this study, we found that innate immune memory is detrimental in stroke, because it promotes the acute
Yi-wei Feng, Yi-wei Feng, Cheng Wu, Feng-yin Liang, Tuo Lin, Tuo Lin, Wan-qi Li, Wan-qi Li, Ying-hua Jing, Pei Dai, Pei Dai, Hui-xian Yu, Hui-xian Yu, Yue Lan, Yue Lan, Zhong Pei, Guang-qing Xu, Guang-qing Xu   +17 more
doaj   +1 more source