Results 31 to 40 of about 604,934 (370)
Nature Communications, 2022 Innate lymphoid cells (ILC) are effector cells that rapidly respond to immune evading stimuli, and despite their functional diversity arise from common precursors.
Carys A. Croft +9 more
doaj +1 more source
InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation [PDF]
, 2012 peer-reviewedInnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes.
Breuer, Karin +9 more
core +1 more source
Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice [PDF]
, 2015 Matrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity which has onco-suppressive actions in numerous tumor ...
A Dufour +62 more
core +3 more sources
Innate Nutritional Immunity [PDF]
The Journal of Immunology, 2018 Abstract Iron (Fe) is an essential micronutrient for both microbes and their hosts. The biologic importance of Fe derives from its inherent ability to act as a universal redox catalyst, co-opted in a variety of biochemical processes critical to maintain life.
Gabriel Núñez +2 more
openaire +3 more sources
Understanding Human Innate Immune System Dependencies using Graph Neural Networks [PDF]
arXiv, 2021 Since the rapid outbreak of Covid-19 and with no approved vaccines to date, profound research interest has emerged to understand the innate immune response to viruses. This understanding can help to inhibit virus replication, prolong adaptive immune response, accelerated virus clearance, and tissue recovery, a key milestone to propose a vaccine to ...
arxiv
RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection
Nature Communications, 2019 RIG-I- like receptors (RLRs) play an important role in immune defense against West Nile virus (WNV). Here, using a systems biology approach, the authors show that macrophage polarization to a proinflammatory M1 phenotype via RIG-I and MDA5 signaling is ...
Amy E. L. Stone +4 more
doaj +1 more source
Exploring The Contribution of Innate Immune Cells to Breast Cancer Immunotherapy [PDF]
arXiv, 2023 Breast cancer is the leading type of cancer in women. About 10-15% of breast cancers are triple-negative breast cancer (TNBC), a subtype with the worst prognosis. Due to the lack of estrogen, progesterone and HER2 receptor expression, chemotherapies have been the standard of care for decades.
arxiv
Innate Immunity to Adenovirus [PDF]
Human Gene Therapy, 2014 Human adenoviruses are the most widely used vectors in gene medicine, with applications ranging from oncolytic therapies to vaccinations, but adenovirus vectors are not without side effects. In addition, natural adenoviruses pose severe risks for immunocompromised people, yet infections are usually mild and self-limiting in immunocompetent individuals.
Hendrickx Rodinde +5 more
openaire +5 more sources
Frontiers in Immunology, 2021 Diabetes-related cognitive dysfunction (DRCD) is a serious complication induced by diabetes. However, there are currently no specific remedies for DRCD. Here, we show that streptozotocin-induced DRCD can be prevented without causing side effects through ...
Haruka Mizobuchi +11 more
doaj +1 more source
Resistance of human leukocytes to vesicular stomatitis virus infection as one of the innate antiviral immune activities; participation of cell subpopulations. [PDF]
, 2008 Among reactions of innate immunity, resistance of human peripheral blood leukocytes (PBL) to viral infection seems important. The purpose of our study was to find, which of the subpopulations of PBL is the most responsible for the innate antiviral ...
Błach-Olszewska, Zofia +3 more
core +2 more sources