Results 31 to 40 of about 2,416,042 (300)

Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases

Frontiers in Immunology, 2020
The emerging concept of microbiota contributing to local mucosal homeostasis has fueled investigation into its specific role in immunology. Gut microbiota is mostly responsible for maintaining the balance between host defense and immune tolerance ...
Yu-hao Jiao, Li Wu, N. Huntington, Xuan Zhang   +3 more
semanticscholar   +1 more source

Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee’s Social Immune System [PDF]

, 2019
Social organisms combat pathogens through individual innate immune responses or through social immunity—behaviors among individuals that limit pathogen transmission within groups.
Currie, Rob, Desai, Suresh, Foster, Leonard, Guarna, Maria Marta, Harpur, Brock, Higo, Heather, Hoover, Shelley, Huxter, Elizabeth, Ibrahim, Abdullah, Melathopoulos, Andony, Moon, Kyung-Mee, Pernal, Stephen, Zayed, Amro   +12 more
core   +1 more source

An ocular Th1 immune response promotes corneal nerve damage independently of the development of corneal epitheliopathy

Journal of Neuroinflammation, 2023
Proper sight is not possible without a smooth, transparent cornea, which is highly exposed to environmental threats. The abundant corneal nerves are interspersed with epithelial cells in the anterior corneal surface and are instrumental to corneal ...
Alexia Vereertbrugghen, Manuela Pizzano, Florencia Sabbione, Irene Angelica Keitelman, Carolina Maiumi Shiromizu, Douglas Vera Aguilar, Federico Fuentes, Cintia S. de Paiva, Mirta Giordano, Analía Trevani, Jeremías G. Galletti   +10 more
doaj   +1 more source

Expression and Localization of Paneth Cells and Their α-Defensins in the Small Intestine of Adult Mouse

Frontiers in Immunology, 2020
Paneth cells contribute to intestinal innate immunity by sensing bacteria and secreting α-defensin. In Institute of Cancer Research (ICR) mice, α-defensin termed cryptdin (Crp) in Paneth cells consists of six major isoforms, Crp1 to 6.
Kiminori Nakamura, Kiminori Nakamura, Yuki Yokoi, Rie Fukaya, Shuya Ohira, Ryuga Shinozaki, Takuto Nishida, Mani Kikuchi, Tokiyoshi Ayabe, Tokiyoshi Ayabe   +9 more
doaj   +1 more source

Trained Innate Immunity, Epigenetics, and Covid-19.

New England Journal of Medicine, 2020
Training Innate Immunity A recent study of immunity in mice showed that the innate immune system can be primed to respond to later bacterial infection through a process called epigenetic scarring, ...
A. Mantovani, M. Netea
semanticscholar   +1 more source

Innate immunity, assessed by plasma NO measurements, is not suppressed during the incubation fast in eiders [PDF]

, 2006
Immunity is hypothesized to share limited resources with other physiological functions and may mediate life history trade-offs, for example between reproduction and survival.
Adamo, Archer, Berczi, Bourgeon, Bourgeon, Crippen, Criscuolo, Criscuolo, Daniel Ricquier, Demas, Demas, Demas, Elizalde, Eraud, Faggioni, François Criscuolo, Gross, Gullo, Guzik, Hamilton, Hangalapura, Hangalapura, Hanssen, Hanssen, Hanssen, Hanssen, Harvey, Hickman-Miller, Jarosinski, Keil, Korschgen, Lillehoj, Lord, Lourenco, Love, Lõhmus, Lõhmus, MacColl, MacDonald, Martin, Nilsson, Nordling, Norris, Ricart-Jané, Ricklefs, Rodriguez, Roitt, Råberg, Salman, Sheldon, Sophie Bourgeon, Svensson, Szabo, Thierry Raclot, Tieleman, Tosi, Verhulst, Viney, von Schantz, Wiersma, Yoccoz, Yvon Le Maho, Zuk   +62 more
core   +3 more sources

Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice [PDF]

, 2015
Matrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity which has onco-suppressive actions in numerous tumor ...
A Dufour, A Gutierrez-Fernandez, A Gutiérrez-Fernández, A Krüger, AM Tester, Ana Gutiérrez-Fernández, B Fingleton, B Fingleton, C López-Otín, C Soria-Valles, CM Overall, CT Guy, D Agarwal, Dylan R Edwards, E Dejonckheere, EI Deryugina, EM Bekes, EY Lin, EY Lin, G Christoffersson, G Dew, H Nozawa, J Decock, J Decock, J Decock, J Decock, J Schindelin, J Wyckoff, JE Maglione, JP Väyrynen, JP Witty, JT Korpi, JT Korpi, Julie Decock, K Almholt, L Sevenich, LH Palavalli, LJ McCawley, M Balbin, M Egeblad, M Hernández, M Lin, M Zhu, MM Gueders, N Fortelny, N Xu, P Li, P Lint Van, S Tazzyman, S Thirkettle, Sally Thirkettle, Stephen D Robinson, T Pellinen, T-Y Wu, V Knäuper, V Montel, W Wang, Wouter Hendrickx, Y Lang, Y-H Lin, Z Yang, Z-G Zhao, ZG Fridlender   +62 more
core   +3 more sources

MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection

mBio, 2023
Influenza A virus (IAV) triggers multiple programmed cell death pathways, including MLKL-dependent necroptosis, caspase-8-dependent apoptosis, and caspase-1-dependent pyroptosis in myeloid cells.
Xuqiu Lei, Yongzhi Chen, Egil Lien, Katherine A. Fitzgerald   +3 more
doaj   +1 more source

Stromule extension along microtubules coordinated with actin-mediated anchoring guides perinuclear chloroplast movement during innate immunity. [PDF]

, 2018
Dynamic tubular extensions from chloroplasts called stromules have recently been shown to connect with nuclei and function during innate immunity. We demonstrate that stromules extend along microtubules (MTs) and MT organization directly affects stromule
Alqarni, Ali, Caplan, Jeffrey Lewis, Dinesh-Kumar, Savithramma P, Hoban, Kyle, Kambhamettu, Chandra, Kumar, Amutha Sampath, McDonald, John H, Modla, Shannon, Nedo, Alexander, Park, Eunsook, Ren, Li   +10 more
core   +3 more sources

Metabolomic Profiling Reveals Distinct and Mutual Effects of Diet and Inflammation in Shaping Systemic Metabolism in Ldlr^−/− Mice

Metabolites, 2020
Changes in modern dietary habits such as consumption of Western-type diets affect physiology on several levels, including metabolism and inflammation. It is currently unclear whether changes in systemic metabolism due to dietary interventions are long ...
Mario A. Lauterbach, Eicke Latz, Anette Christ   +2 more
doaj   +1 more source