Results 41 to 50 of about 737,433 (332)

Metabolomic Profiling Reveals Distinct and Mutual Effects of Diet and Inflammation in Shaping Systemic Metabolism in Ldlr−/− Mice

open access: yesMetabolites, 2020
Changes in modern dietary habits such as consumption of Western-type diets affect physiology on several levels, including metabolism and inflammation. It is currently unclear whether changes in systemic metabolism due to dietary interventions are long ...
Mario A. Lauterbach   +2 more
doaj   +1 more source

Reviewing the effects of food provisioning on wildlife immunity [PDF]

open access: yes, 2018
While urban expansion increasingly encroaches on natural habitats, many wildlife species capitalize on anthropogenic food resources, which have the potential to both positively and negatively influence their responses to infection.
Babayan, Simon A.   +2 more
core   +1 more source

Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation

open access: yesNature Communications, 2022
Innate lymphoid cells (ILC) are effector cells that rapidly respond to immune evading stimuli, and despite their functional diversity arise from common precursors.
Carys A. Croft   +9 more
doaj   +1 more source

Hypercytokinemia: Increased or decreased innate immunity? [PDF]

open access: yes, 2008
The adipose tissue is an active endocrine organ which secretes proinflammatory cytokines and chemokines resulting into raised serum levels. Hypercytokinemia has been interpreted as raised level of innate immunity and its evolution is interpreted as a ...
Milind Watve   +2 more
core   +2 more sources

Aging and Innate Immunity [PDF]

open access: yesImmunity, 2006
Adaptive immunity undergoes severe deterioration with age and represents the main problem in the elderly. However, evidence accumulated over the last decade supports the hypothesis that aging also has a profound impact on innate immunity, which in turn markedly impacts the health and longevity of older people.
Rafael Solana   +2 more
openaire   +3 more sources

RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection

open access: yesNature Communications, 2019
RIG-I- like receptors (RLRs) play an important role in immune defense against West Nile virus (WNV). Here, using a systems biology approach, the authors show that macrophage polarization to a proinflammatory M1 phenotype via RIG-I and MDA5 signaling is ...
Amy E. L. Stone   +4 more
doaj   +1 more source

Predictors and immunological correlates of sublethal mercury exposure in vampire bats [PDF]

open access: yes, 2017
Mercury (Hg) is a pervasive heavy metal that often enters the environment from anthropogenic sources such as gold mining and agriculture. Chronic exposure to Hg can impair immune function, reducing the ability of animals to resist or recover from ...
Altizer, Sonia   +7 more
core   +1 more source

Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]

open access: yes, 2020
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia   +4 more
core   +2 more sources

Insights on adaptive and innate immunity in canine leishmaniosis [PDF]

open access: yes, 2016
Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities.
Abi Abdallah   +19 more
core   +3 more sources

Mosquito Innate Immunity [PDF]

open access: yesInsects, 2018
Mosquitoes live under the endless threat of infections from different kinds of pathogens such as bacteria, parasites, and viruses. The mosquito defends itself by employing both physical and physiological barriers that resist the entry of the pathogen and the subsequent establishment of the pathogen within the mosquito.
Ankit Kumar   +6 more
openaire   +3 more sources

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