Results 41 to 50 of about 2,416,042 (300)
InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation [PDF]
, 2012 peer-reviewedInnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes.
Breuer, Karin +9 more
core +1 more source
Innate Immunity to Adenovirus [PDF]
Human Gene Therapy, 2014 Human adenoviruses are the most widely used vectors in gene medicine, with applications ranging from oncolytic therapies to vaccinations, but adenovirus vectors are not without side effects. In addition, natural adenoviruses pose severe risks for immunocompromised people, yet infections are usually mild and self-limiting in immunocompetent individuals.
Hendrickx Rodinde +5 more
openaire +5 more sources
Hypoxia and Innate Immunity: Keeping Up with the HIFsters.
Annual Review of Immunology, 2020 Recent years have witnessed an emergence of interest in understanding metabolic changes associated with immune responses, termed immunometabolism. As oxygen is central to all aerobic metabolism, hypoxia is now recognized to contribute fundamentally to ...
S. Colgan, G. Furuta, C. Taylor
semanticscholar +1 more source
Nature Communications, 2022 Innate lymphoid cells (ILC) are effector cells that rapidly respond to immune evading stimuli, and despite their functional diversity arise from common precursors.
Carys A. Croft +9 more
doaj +1 more source
Hypoxia-inducible factors and innate immunity in liver cancer.
Journal of Clinical Investigation, 2020 The liver has strong innate immunity to counteract pathogens from the gastrointestinal tract. During the development of liver cancer, which is typically driven by chronic inflammation, the composition and biological roles of the innate immune cells are ...
V. W. Yuen, C. C. Wong
semanticscholar +1 more source
Mosquito Innate Immunity [PDF]
Insects, 2018 Mosquitoes live under the endless threat of infections from different kinds of pathogens such as bacteria, parasites, and viruses. The mosquito defends itself by employing both physical and physiological barriers that resist the entry of the pathogen and the subsequent establishment of the pathogen within the mosquito.
Ankit Kumar +6 more
openaire +3 more sources
HIV and innate immunity ? a genomics perspective [PDF]
, 2010 Innate immunity is a theme of increasing interest for HIV research. However, the term is overstretched to cover biological barriers, cellular systems, soluble factors, signaling pathways, and effectors and is inconsistently applied.
Rausell, A., McLaren, P.J., Telenti, A.
core +4 more sources
RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection
Nature Communications, 2019 RIG-I- like receptors (RLRs) play an important role in immune defense against West Nile virus (WNV). Here, using a systems biology approach, the authors show that macrophage polarization to a proinflammatory M1 phenotype via RIG-I and MDA5 signaling is ...
Amy E. L. Stone +4 more
doaj +1 more source
Innate immunity: ignored for decades, but not forgotten. [PDF]
, 2012 The innate immune system must recognize and rapidly respond to microbial pathogens, providing a first line of host defense. This is accomplished through an array of pattern recognition receptors (PRRs) that reside in specific subcellular compartments and
Adam +53 more
core +1 more source
Aging and Innate Immunity [PDF]
Immunity, 2006 Adaptive immunity undergoes severe deterioration with age and represents the main problem in the elderly. However, evidence accumulated over the last decade supports the hypothesis that aging also has a profound impact on innate immunity, which in turn markedly impacts the health and longevity of older people.
Rafael Solana +2 more
openaire +3 more sources