Results 41 to 50 of about 2,613,171 (336)

The Race between Host Antiviral Innate Immunity and the Immune Evasion Strategies of Herpes Simplex Virus 1

Microbiology and Molecular Biology Reviews, 2020
Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and latent infections in humans by counteracting host antiviral innate immune responses.
Huifang Zhu, C. Zheng
semanticscholar   +1 more source

RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection

Nature Communications, 2019
RIG-I- like receptors (RLRs) play an important role in immune defense against West Nile virus (WNV). Here, using a systems biology approach, the authors show that macrophage polarization to a proinflammatory M1 phenotype via RIG-I and MDA5 signaling is ...
Amy E. L. Stone, Richard Green, Courtney Wilkins, Emily A. Hemann, Michael Gale   +4 more
doaj   +1 more source

Insights on adaptive and innate immunity in canine leishmaniosis [PDF]

, 2016
Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities.
Abi Abdallah, Alexander, Catchpole, DAMER P. BLAKE, de Souza Carmo, Green, Kensil, LAIA SOLANO-GALLEGO, Lopez, Margarito, Ordeix, Pinelli, Pitta, Quinnell, Sadick, Sanchez, SHAZIA HOSEIN, Silva, Vouldoukis, Wakelin   +19 more
core   +4 more sources

Prevention of Diabetes-Associated Cognitive Dysfunction Through Oral Administration of Lipopolysaccharide Derived From Pantoea agglomerans

Frontiers in Immunology, 2021
Diabetes-related cognitive dysfunction (DRCD) is a serious complication induced by diabetes. However, there are currently no specific remedies for DRCD. Here, we show that streptozotocin-induced DRCD can be prevented without causing side effects through ...
Haruka Mizobuchi, Kazushi Yamamoto, Masashi Yamashita, Yoko Nakata, Hiroyuki Inagawa, Hiroyuki Inagawa, Hiroyuki Inagawa, Chie Kohchi, Chie Kohchi, Gen-Ichiro Soma, Gen-Ichiro Soma, Gen-Ichiro Soma   +11 more
doaj   +1 more source

Innate immunity, assessed by plasma NO measurements, is not suppressed during the incubation fast in eiders [PDF]

, 2006
Immunity is hypothesized to share limited resources with other physiological functions and may mediate life history trade-offs, for example between reproduction and survival.
Adamo, Archer, Berczi, Bourgeon, Bourgeon, Crippen, Criscuolo, Criscuolo, Daniel Ricquier, Demas, Demas, Demas, Elizalde, Eraud, Faggioni, François Criscuolo, Gross, Gullo, Guzik, Hamilton, Hangalapura, Hangalapura, Hanssen, Hanssen, Hanssen, Hanssen, Harvey, Hickman-Miller, Jarosinski, Keil, Korschgen, Lillehoj, Lord, Lourenco, Love, Lõhmus, Lõhmus, MacColl, MacDonald, Martin, Nilsson, Nordling, Norris, Ricart-Jané, Ricklefs, Rodriguez, Roitt, Råberg, Salman, Sheldon, Sophie Bourgeon, Svensson, Szabo, Thierry Raclot, Tieleman, Tosi, Verhulst, Viney, von Schantz, Wiersma, Yoccoz, Yvon Le Maho, Zuk   +62 more
core   +3 more sources

Baseline data collections of lipopolysaccharide content in 414 herbal extracts and its role in innate immune activation

Scientific Reports
Some herbal extracts contain relatively high amounts of lipopolysaccharide (LPS). Because orally administered LPS activates innate immunity without inducing inflammation, it plays a role as an active ingredient in herbal extracts.
Vindy Tjendana Tjhin, Masataka Oda, Masashi Yamashita, Tomoko Iwaki, Yasuko Fujita, Koji Wakame, Hiroyuki Inagawa, Gen-Ichiro Soma   +7 more
doaj   +1 more source

Hypoxia and Innate Immunity: Keeping Up with the HIFsters.

Annual Review of Immunology, 2020
Recent years have witnessed an emergence of interest in understanding metabolic changes associated with immune responses, termed immunometabolism. As oxygen is central to all aerobic metabolism, hypoxia is now recognized to contribute fundamentally to ...
S. Colgan, G. Furuta, C. Taylor
semanticscholar   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application

Nature Communications
Inflammasome activation results in the cleavage of gasdermin D (GSDMD) by pro-inflammatory caspases. The N-terminal domains (GSDMDNT) oligomerize and assemble pores penetrating the target membrane.
Lisa D. J. Schiffelers, Yonas M. Tesfamariam, Lea-Marie Jenster, Stefan Diehl, Sophie C. Binder, Sabine Normann, Jonathan Mayr, Steffen Pritzl, Elena Hagelauer, Anja Kopp, Assaf Alon, Matthias Geyer, Hidde L. Ploegh, Florian I. Schmidt   +13 more
doaj   +1 more source

Predictors and immunological correlates of sublethal mercury exposure in vampire bats [PDF]

, 2017
Mercury (Hg) is a pervasive heavy metal that often enters the environment from anthropogenic sources such as gold mining and agriculture. Chronic exposure to Hg can impair immune function, reducing the ability of animals to resist or recover from ...
Altizer, Sonia, Becker, Daniel J., Bentz, Alexandra B., Chumchal, Matthew M., Czirják, Gábor Á., Platt, Steven G., Rainwater, Thomas R., Streicker, Daniel G.   +7 more
core   +1 more source