Results 71 to 80 of about 730,043 (275)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Interleukin-1β Signaling in Dendritic Cells Induces Antiviral Interferon Responses

mBio, 2018
Induction of interferon beta (IFN-β), IFN-stimulated genes (ISGs), and inflammatory responses is critical for control of viral infection. We recently identified an essential linkage of stimulation of the inflammatory cytokine interleukin-1β (IL-1β) and ...
Lauren D. Aarreberg, Courtney Wilkins, Hilario J. Ramos, Richard Green, Michael A. Davis, Kwan Chow, Michael Gale   +6 more
doaj   +1 more source

PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. [PDF]

, 2019
Inflammation is an essential aspect of innate immunity but also contributes to diverse human diseases. Although much is known about the kinases that control inflammatory signaling, less is known about the opposing phosphatases.
Cohen Katsenelson, Ksenya, Glass, Christopher K, Kawashima, Agnieszka T, Lordén, Gema, Newton, Alexandra C, Nizet, Victor, Stender, Joshua D, Uchiyama, Satoshi   +7 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise

Communications Biology, 2023
NLRP1, while the first inflammasome described, has only recently begun to gain significant attention in disease pathology, inflammation research, and potentially, as a therapeutic target. Recently identified human variants provide key insights into NLRP1
Kristian Barry, Christopher Murphy, Ashley Mansell   +2 more
doaj   +1 more source

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses. [PDF]

, 2018
Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely ...
A Marusyk, AD Rouillard, Amir Reza Aref, AN Hata, Anika Elise Adeni, AR Aref, Brandon Piel, C Henke, Camilla Laulund Christensen, CD Carey, Christine Anne Lydon, CL Christensen, Cloud Peter Paweletz, D Gao, D Hanahan, D Miao, D Pan, D Peng, D Roulois, DA Barbie, DA Rhodes, David Allen Barbie, Debattama Rai. Sen, Diana Miao, DJ Konieczkowski, DP Tabassum, DR Sen, EB Chuong, Evisa Gjini, Ewa Sicinska, F Perocchi, G Bindea, Gao Zhang, Hideki Terai, Hideo Baba, Hideo Watanabe, I Canadas, I Tirosh, Israel Cañadas, J Barretina, J Calbo, J Chen, Jacob Sands, JG Doench, Jong Wook Kim, JT Poirier, JW Kim, KA Hoadley, KB Chiappinelli, Kwok Kin Wong, Lynnette Marie Sholl, Marco Campisi, Masayuki Watanabe, Meenhard Herlyn, MR Junttila, NE Sanjana, O Shalem, Pablo Tamayo, Ravindra Uppaluri, Rohit Thummalapalli, RT Manguso, Russell William Jenkins, RW Jenkins, Scott Rodig, Shohei Koyama, Shunsuke Kitajima, Thanh Uyen Barbie, Tian Tian, Timothy Hagan, Tran Thai, X Wu, Y Qiao, Yanan Kuang, Yanxi Zhang, Yu Imamura, Zhi Wei   +75 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Immunomodulatory Effects and Protection in Sepsis by the Antibiotic Moxifloxacin

Antibiotics
Sepsis is a leading cause of death in Intensive Care Units. Despite its prevalence, sepsis remains insufficiently understood, with no substantial qualitative improvements in its treatment in the past decades.
Tiago R. Velho, Helena Raquel, Nuno Figueiredo, Ana Neves-Costa, Dora Pedroso, Isa Santos, Katharina Willmann, Luís F. Moita   +7 more
doaj   +1 more source

Understanding diversity of human innate immunity receptors: analysis of surface features of leucine-rich repeat domains in NLRs and TLRs. [PDF]

, 2009
BackgroundThe human innate immune system uses a system of extracellular Toll-like receptors (TLRs) and intracellular Nod-like receptors (NLRs) to match the appropriate level of immune response to the level of threat from the current environment.
Godzik, Adam, Istomin, Andrei Y
core   +4 more sources