Results 71 to 80 of about 737,433 (332)
Innate immune regulation in HIV latency models
Retrovirology, 2022 Background Innate immunity and type 1 interferon (IFN) defenses are critical for early control of HIV infection within CD4 + T cells. Despite these defenses, some acutely infected cells silence viral transcription to become latently infected and form the
Rebecca M. Olson +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Innate Nutritional Immunity [PDF]
The Journal of Immunology, 2018 Abstract Iron (Fe) is an essential micronutrient for both microbes and their hosts. The biologic importance of Fe derives from its inherent ability to act as a universal redox catalyst, co-opted in a variety of biochemical processes critical to maintain life.
Gabriel Núñez +2 more
openaire +3 more sources
QTL affecting innate immunity in Dutch dairy cattle [PDF]
, 2014 Unique features of immunity early in life include a distinct immune system particularly reliant on innate immunity, with weak T helper (Th)1-polarizing immune responses, and impaired responses to certain vaccines leading to a heightened susceptibility to
Arendonk, J.A.M., van +7 more
core +6 more sources
IFNα and IFNγ Impede Marek’s Disease Progression [PDF]
, 2019 Marek’s disease virus (MDV) is an alphaherpesvirus that causes Marek’s disease, a malignant lymphoproliferative disease of domestic chickens. While MDV vaccines protect animals from clinical disease, they do not provide sterilizing immunity and allow ...
Bertzbach, Luca D. +6 more
core +1 more source
Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes
EMBO Molecular MedicineIn humans, blood Classical CD14+ monocytes contribute to host defense by secreting large amounts of pro-inflammatory cytokines. Their aberrant activity causes hyper-inflammation and life-threatening cytokine storms, while dysfunctional monocytes are ...
Ibrahim Hawwari +16 more
doaj +1 more source
SpermQ–A Simple Analysis Software to Comprehensively Study Flagellar Beating and Sperm Steering
Cells, 2018 Motile cilia, also called flagella, are found across a broad range of species; some cilia propel prokaryotes and eukaryotic cells like sperm, while cilia on epithelial surfaces create complex fluid patterns e.g., in the brain or lung.
Jan N. Hansen +3 more
doaj +1 more source
STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
Nature Communications, 2020 TLR4 signalling can reprogram the metabolism of macrophages to be more glycolytic and proinflammatory. Here the authors show that LPS and TLR4 signalling results in recruitment of TBK1, which in turn phosphorylates serine 727 on STAT3 to enable a ...
Jesse J. Balic +14 more
doaj +1 more source
Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death
Viruses, 2020 Influenza A virus (IAV) is a major concern to human health due to the ongoing global threat of a pandemic. Inflammatory and cell death signalling pathways play important roles in host defence against IAV infection.
Gabriel Laghlali +2 more
doaj +1 more source