Results 71 to 80 of about 2,416,042 (300)
STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
Nature Communications, 2020 TLR4 signalling can reprogram the metabolism of macrophages to be more glycolytic and proinflammatory. Here the authors show that LPS and TLR4 signalling results in recruitment of TBK1, which in turn phosphorylates serine 727 on STAT3 to enable a ...
Jesse J. Balic +14 more
doaj +1 more source
Innate immune regulation in HIV latency models
Retrovirology, 2022 Background Innate immunity and type 1 interferon (IFN) defenses are critical for early control of HIV infection within CD4 + T cells. Despite these defenses, some acutely infected cells silence viral transcription to become latently infected and form the
Rebecca M. Olson +8 more
doaj +1 more source
Subversion of host innate immunity by uropathogenic Escherichia coli [PDF]
, 2016 Uropathogenic Escherichia coli (UPEC) cause the majority of community-onset urinary tract infections (UTI) and represent a major etiologic agent of healthcare-associated UTI.
Cavalieri +5 more
core +3 more sources
Mitochondria in innate immunity [PDF]
EMBO reports, 2011 Mitochondria are cellular organelles involved in host‐cell metabolic processes and the control of programmed cell death. A direct link between mitochondria and innate immune signalling was first highlighted with the identification of MAVS—a crucial adaptor for RIGI‐like receptor signalling—as a mitochondria‐anchored protein.
Arnoult D +3 more
openaire +3 more sources
A functional DC cross talk promotes human ILC homeostasis in humanized mice
Blood Advances, 2017 : Humanized mice harboring human hematopoietic systems offer a valuable small-animal model to assess human immune responses to infection, inflammation, and cancer.
Silvia Lopez-Lastra +8 more
doaj
Innate immunity in allergy [PDF]
Allergy, 2019 AbstractInnate immune system quickly responds to invasion of microbes and foreign substances through the extracellular and intracellular sensing receptors, which recognize distinctive molecular and structural patterns. The recognition of innate immune receptors leads to the induction of inflammatory and adaptive immune responses by activating ...
Kazuhiko Maeda +2 more
openaire +3 more sources
Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes
EMBO Molecular MedicineIn humans, blood Classical CD14+ monocytes contribute to host defense by secreting large amounts of pro-inflammatory cytokines. Their aberrant activity causes hyper-inflammation and life-threatening cytokine storms, while dysfunctional monocytes are ...
Ibrahim Hawwari +16 more
doaj +1 more source
Interleukin-1β Signaling in Dendritic Cells Induces Antiviral Interferon Responses
mBio, 2018 Induction of interferon beta (IFN-β), IFN-stimulated genes (ISGs), and inflammatory responses is critical for control of viral infection. We recently identified an essential linkage of stimulation of the inflammatory cytokine interleukin-1β (IL-1β) and ...
Lauren D. Aarreberg +6 more
doaj +1 more source
NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise
Communications Biology, 2023 NLRP1, while the first inflammasome described, has only recently begun to gain significant attention in disease pathology, inflammation research, and potentially, as a therapeutic target. Recently identified human variants provide key insights into NLRP1
Kristian Barry +2 more
doaj +1 more source
Insights on adaptive and innate immunity in canine leishmaniosis [PDF]
, 2016 Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities.
Abi Abdallah +19 more
core +3 more sources