Results 191 to 200 of about 182,908 (236)

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Circadian-clock-controlled endocrine and cytokine signals regulate multipotential innate lymphoid cell progenitors in the bone marrow. [PDF]

Cell Rep
Liu Q, Tabrez S, Niekamp P, Kim CH.
europepmc   +1 more source

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, EarlyView.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source

Innovative γ‐Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery

Small, EarlyView.
Identified through multi‐stage selection process, a formulation combining γ‐oryzanol and DLin‐KC2‐DMA, termed as OryKL, demonstrates unique nano‐structural features, highly efficient mRNA transfection and functional integrity during long‐term storage, enables broad biodistribution and distinct cell tropism following intravenous administration with no ...
Pengkai Shi, Haikun Liu, Ahmed Refaat, Hung Nguyen, Anne Nguyen, Kaiting Miao, Yuyang Song, Sylvain Trépout, Rico F. Tabor, Liliana de Campo, Karlheinz Peter, Mark Louis P. Vidallon, Xiaowei Wang   +12 more
wiley   +1 more source

A diversity of novel type-2 innate lymphoid cell subpopulations revealed during tumour expansion. [PDF]

Commun Biol
Xia CW, Saranchova I, Finkel PL, Besoiu S, Munro L, Pfeifer CG, Haegert A, Lin YY, Le Bihan S, Collins C, Jefferies WA.   +10 more
europepmc   +1 more source

In Vivo Microendoscopy in the Near‐Infrared II Window

Small, EarlyView.
NIR‐II microendoscopy with imaging wavelength extended to 1700 nm, enabling deep intestinal imaging beyond the mucosa and transrectal imaging at cellular resolution without any invasive surgery. It facilitates visualization of the relative motion of vascular networks, lymphatic drainage, and lesions in colitis models, opening new possibilities for ...
Zhisheng Wu, Danyang Xu, Zideng Dai, Xinyuan Wang, Wayne Jason Li, Sixin Xu, Xun Zhang, Yuanhua Liu, Puxian Xiong, Hanze Yu, Wentao Ye, Liangqiong Qu, Yongye Liang, Hongjie Dai, Feifei Wang   +14 more
wiley   +1 more source

Sex Hormones and the Risk of Nasal Polyps: A Two‐Sample Mendelian Randomization Study

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective The pathophysiological roles of sex hormones in airway inflammation have drawn much attention recently. We aimed to explore the causal effect of sex hormones on chronic rhinosinusitis (CRS) and nasal polyps (NP) via a Mendelian randomization (MR) study.
Ying Zhu, Jia‐Yao Zhou, Shi‐Yao Zhang, Ru Tang, Chun‐Yu Luo, Yue‐Long Gu, Zhi‐Peng Li, Wei‐Tian Zhang   +7 more
wiley   +1 more source

Identification and validation of a novel innate lymphoid cell-based signature to predict prognosis and immune response in liver cancer by integrated single-cell RNA analysis and bulk RNA sequencing. [PDF]

Transl Cancer Res
Pan M, Yuan X, Peng J, Wu R, Chen X.
europepmc   +1 more source

Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang, Teng‐Fei Li, Tian‐Yu Wang, Huan‐Hai Liu   +3 more
wiley   +1 more source

Mycosis Fungoides Is a Proliferation of Multiple Mutational Subclones

The Journal of Dermatology, EarlyView.
ABSTRACT Mycosis fungoides (MF) is a unique type of lymphoma with an excellent prognosis presenting with a wide variety of clinical and histological findings. Recent sophisticated research techniques have revealed that very slow changes in the clinical and histological pictures of one patient over time are due to intratumoral heterogeneity.
Ryoma Honda, Toshihisa Hamada, Makoto Sugaya   +2 more
wiley   +1 more source