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Allergy, EarlyView.Oxazolone exposure drives rapid basophil recruitment to wounded skin, accelerating re‐epithelialization, angiogenesis, and tissue regeneration. Basophils are the dominant early source of IL‐4 and IL‐13 in the wound microenvironment. Basophil‐derived IL‐4/IL‐13 promote macrophage polarization toward a pro‐repair M2 phenotype, enabling efficient wound ...
Yufei Zhang +14 more
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Selective Targeting of IL‐1RAP‐Dependent Eosinophilic Inflammation in Allergic Fungal Airway Disease
Allergy, EarlyView.
Thomas J. Williams +7 more
wiley +1 more source
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Innate lymphoid cell development
Journal of Allergy and Clinical Immunology, 2021Innate lymphoid cells (ILCs) mainly reside at barrier surfaces and regulate tissue homeostasis and immunity. ILCs are divided into 3 groups, group 1 ILCs, group 2 ILCs, and group 3 ILC3, on the basis of their similar effector programs to T cells. The development of ILCs from lymphoid progenitors in adult mouse bone marrow has been studied in detail ...
Maryam, Ghaedi, Fumio, Takei
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Blood, 2014
Innate lymphoid cells (ILCs) are lymphoid cells that do not express rearranged receptors and have important effector and regulatory functions in innate immunity and tissue remodeling. ILCs are categorized into 3 groups based on their distinct patterns of cytokine production and the requirement of particular transcription factors for their development ...
M. D. Hazenberg, H. Spits
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Innate lymphoid cells (ILCs) are lymphoid cells that do not express rearranged receptors and have important effector and regulatory functions in innate immunity and tissue remodeling. ILCs are categorized into 3 groups based on their distinct patterns of cytokine production and the requirement of particular transcription factors for their development ...
M. D. Hazenberg, H. Spits
openaire +4 more sources
2020
Innate lymphoid cells (ILCs) have come to the forefront of mucosal immunology, being recognized as prompt effectors against infection and injury, and as orchestrators of immune responses. The ILC subsets react to different cues in their local environment to mount qualitatively different effector responses, depending on the type of infection or tissue ...
Gerard Eberl, Nicholas Powell
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Innate lymphoid cells (ILCs) have come to the forefront of mucosal immunology, being recognized as prompt effectors against infection and injury, and as orchestrators of immune responses. The ILC subsets react to different cues in their local environment to mount qualitatively different effector responses, depending on the type of infection or tissue ...
Gerard Eberl, Nicholas Powell
openaire +2 more sources
Immunity without innate lymphoid cells
Nature Immunology, 2016A cohort of immunodeficient children lead near-normal lives after bone marrow transplantation, despite a profound deficiency of innate lymphoid cells (ILCs).
Weinkove, Robert +2 more
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Development of innate lymphoid cells
Nature Immunology, 2016Innate lymphoid cells (ILCs) are a family of immune effector cells that have important roles in host defense, metabolic homeostasis and tissue repair but can also contribute to inflammatory diseases such as asthma and colitis. These cells can be categorized into three groups on the basis of the transcription factors that direct their function and the ...
Erin C, Zook, Barbara L, Kee
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Innate Lymphoid Cells in Cancer
Cancer Immunology Research, 2015AbstractThe world of lymphocytes has recently expanded. A group of cells, innate lymphoid cells (ILC), has been defined. It includes lymphoid cells that have been known for decades, such as natural killer (NK) cells and lymphoid tissue–inducer (LTi) cells. NK cells recognize a vast array of tumor cells, which they help to eliminate through cytotoxicity
B. Vallentin +9 more
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Innate lymphoid cells in atherosclerosis
European Journal of Pharmacology, 2017The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions.
Daniel, Engelbertsen, Andrew H, Lichtman
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