Results 221 to 230 of about 182,908 (236)

The Innate Lymphoid Cell Precursor

Annual Review of Immunology, 2016
The discovery of tissue-resident innate lymphoid cell populations effecting different forms of type 1, 2, and 3 immunity; tissue repair; and immune regulation has transformed our understanding of mucosal immunity and allergy. The emerging complexity of these populations along with compounding issues of redundancy and plasticity raise intriguing ...
Isabel E, Ishizuka, Michael G, Constantinides, Herman, Gudjonson, Albert, Bendelac   +3 more
openaire   +2 more sources

Innate lymphoid cells and asthma

Journal of Allergy and Clinical Immunology, 2014
Asthma is a complex and heterogeneous disease with several phenotypes, including an allergic asthma phenotype characterized by TH2 cytokine production and associated with allergen sensitization and adaptive immunity. Asthma also includes nonallergic asthma phenotypes, such as asthma associated with exposure to air pollution, infection, or obesity, that
Sanhong, Yu, Hye Young, Kim, Ya-Jen, Chang, Rosemarie H, DeKruyff, Dale T, Umetsu   +4 more
openaire   +2 more sources

Plasticity of innate lymphoid cell subsets

Nature Reviews Immunology, 2020
Innate lymphoid cells (ILCs) are important for tissue homeostasis and for the initiation of immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can be categorized into five subsets with defined phenotypes and functional profiles, but they also have the ability to adapt to local environmental cues by changing these ...
Suzanne M. Bal, Korneliusz Golebski, Hergen Spits   +2 more
openaire   +2 more sources

Early Development of Innate Lymphoid Cells

2022
Innate lymphoid cells (ILCs) are transcriptionally and functionally similar to T cells but lack adaptive antigen receptors. They play critical roles in early defense against pathogens. In this review, we summarize recent discoveries of ILC progenitors and discuss possible mechanisms that separate ILCs from T cells.
Ding, Yi, Harly, Christelle, Das, Arundhoti, Bhandoola, Avinash   +3 more
openaire   +3 more sources

Immunophenotyping of Human Innate Lymphoid Cells

2019
In the last years, the family of innate lymphocytes has been growing following the discovery of innate lymphoid cells (ILCs). ILCs are lymphocytes able to rapidly produce a wide range of soluble mediators in an antigen-independent fashion. So far, three main subsets of ILCs have been discovered, ILC1, ILC2, and ILC3, expressing respectively the ...
Trabanelli, Sara, Gomez Cadena, Alejandra, Jandus, Camilla   +2 more
openaire   +3 more sources

Innate Lymphoid Cell Relations

Science, 2010
A common progenitor cell gives rise to distinct lineages of innate lymphoid cells in the gastrointestinal tract.
Marc Veldhoen, David R. Withers
openaire   +1 more source

The discovery of innate lymphoid cells

Nature Reviews Immunology, 2021
Eric Vivier describes the unexpected discovery of new populations of innate-like lymphocytes and the development of the innate lymphoid cell nomenclature.
openaire   +2 more sources

Innate Lymphoid cells

Pancreatology, 2023
Stela Monk, Halim Group
openaire   +1 more source

Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology.

Science (New York, N.Y.), 2015
Innate lymphoid cells (ILCs) are a growing family of immune cells that mirror the phenotypes and functions of T cells. However, in contrast to T cells, ILCs do not express acquired antigen receptors or undergo clonal selection and expansion when stimulated. Instead, ILCs react promptly to signals from infected or injured tissues and produce an array of
Gérard, Eberl, Marco, Colonna, James P, Di Santo, Andrew N J, McKenzie   +3 more
openaire   +1 more source

Epigenetic regulation of innate lymphoid cells

European Journal of Immunology
Abstract Innate lymphoid cells (ILCs) lack antigen‐specific receptors and are considered the innate arm of the immune system, phenotypically and functionally mirroring CD4 + helper T cells.
Hanxiao, Sun, Jinxin, Qiu, Ju, Qiu
openaire   +2 more sources