Results 41 to 50 of about 345,353 (226)

Neutron star mergers chirp about vacuum energy

Journal of High Energy Physics, 2018
Observations of gravitational waves from neutron star mergers open up novel directions for exploring fundamental physics: they offer the first access to the structure of objects with a non-negligible contribution from vacuum energy to their total mass ...
Csaba Csáki, Cem Eröncel, Jay Hubisz, Gabriele Rigo, John Terning   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Release mechanisms of PLGA microparticles prepared using a microfluidics device or a beaker

International Journal of Pharmaceutics: X
The aim of this study was to better understand the release mechanisms of poly(lactic-co-glycolic acid) (PLGA) microparticles prepared via emulsification - solvent extraction/evaporation using a “classical beaker” vs. a “microfluidics device”.
L.A. Lefol, A. Sodano, P. Bawuah, J.A. Zeitler, J. Verin, F. Danede, J.F. Willart, J. Siepmann, F. Siepmann   +8 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Application of New Structure on Power House with Large Variable Tailwater in Karst Area

Renmin Zhujiang, 2020
The power house behind Jiayan dam in Guizhou Province is located in Karst area.Affectedby the backwater effect of underground river, the tailwater head of power plant reaches 44.92 m,and the retaining height is equivalent to a gravity dam in medium ...
GUAN Zhibao, ZHANG Pingjun, YANG Wen, FENG Chuqiao   +3 more
doaj  

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

How do inner and outer settings affect implementation of a community-based innovation for older adults with a serious illness: a qualitative study

BMC Health Services Research, 2021
Background Implementing community-based innovations for older adults with serious illness, who are appropriate for a palliative approach to care, requires developing partnerships between health and community.
Grace Warner, Emily Kervin, Barb Pesut, Robin Urquhart, Wendy Duggleby, Taylor Hill   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source