Results 71 to 80 of about 1,282,933 (259)
RIPK4 function interferes with melanoma cell adhesion and metastasis
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Application of New Structure on Power House with Large Variable Tailwater in Karst Area
The power house behind Jiayan dam in Guizhou Province is located in Karst area.Affectedby the backwater effect of underground river, the tailwater head of power plant reaches 44.92 m,and the retaining height is equivalent to a gravity dam in medium ...
GUAN Zhibao +3 more
doaj
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Harbor terminals and urban sewage effluents affect the composition and distribution of epibenthic organisms. In this study, we hypothesized that the benthic community structure at the Vitoria Harbor changes spatially in a ~3 km scale, and that these ...
Ilana Rosental Zalmon +2 more
doaj +1 more source
Molecular Basis and Consequences of the Cytochrome c-tRNA Interaction. [PDF]
The intrinsic apoptosis pathway occurs through the release of mitochondrial cytochrome c to the cytosol, where it promotes activation of the caspase family of proteases.
Christian, Thomas +6 more
core +2 more sources
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
An Integrated Tracker for STAR [PDF]
The STAR experiment at the Relativistic Heavy Ion Collider RHIC studies the new state of matter produced in relativistic heavy ion collisions and the spin structure of the nucleon in collisions of polarized protons.
Adams, J +7 more
core +2 more sources
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
A Dispersed Multi-Value Attribute-Based Encryption With Mediated Obfuscation
The Multi-authority attribute-based encryption (MA-ABE) scheme can provide fine-grained data access control in many management domains monitored by different authorities for the cloud storage system.
Shengzhou Hu, Jiguo Li, Yichen Zhang
doaj +1 more source

