LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB)
Signal Transduction and Targeted Therapy, 2022 Inner ear disorders are a cluster of diseases that cause hearing loss in more than 1.5 billion people worldwide. However, the presence of the blood-labyrinth barrier (BLB) on the surface of the inner ear capillaries greatly hinders the effectiveness of ...
Xi Shi +25 more
doaj +1 more source
Microwave‐Assisted Aqueous Synthesis of Gelatin‐Norbornene for Hydrogel Crosslinking and Bioprinting
Advanced Materials Technologies, EarlyView.A microwave‐assisted reaction is utilized to synthesize gelatin‐norbornene (GelNB), achieving a high degree of norbornene functionalization while reducing the macromer's upper critical solution temperature. The resulting GelNB macromer has high solubility at room temperature, facilitating light‐based 3‐dimensional (3D) printing of thiol‐norbornene ...
Jonathan B. Bryan, Chien‐Chi Lin
wiley +1 more source
Radiation Oncology, 2020 Background In addition to the direct effects of irradiation, the induced inflammatory response may play an important role in the damage to the inner ear caused by radiotherapy for the treatment of head and neck cancers.
Jie Zhang +8 more
doaj +1 more source
Perilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs [PDF]
, 2017 Patients undergoing cochlear implantation could benefit from a simultaneous application of drugs into the ear, helping preserve residual low-frequency hearing and afferent nerve fiber populations.
Salt, Alec +5 more
core +3 more sources
A Degradable Device for Sustainable Capillary Blood Sampling
Advanced Materials Technologies, EarlyView.The device features a compostable 3D‐printed storage compartment for liquid blood collection and a degradable, poly(ɛ‐caprolactone)‐coated magnesium microneedle patch hidden within a suction cup. Manual compression deploys the MNs, creating small skin punctures, and the subsequent release of compression generates the negative pressure required for ...
Nicole Zoratto +5 more
wiley +1 more source
The Blood-Labyrinth Barrier: Non-Invasive Delivery Strategies for Inner Ear Drug Delivery
PharmaceuticsThe inner ear is a relatively isolated organ, protected by the blood-labyrinth barrier (BLB). This barrier creates a unique lymphatic fluid environment within the inner ear, maintaining a stable physiological state essential for the mechano-electrical ...
Zhangyi Yi +3 more
doaj +1 more source
Cochlear Implant Outcomes and Genetic Mutations in Children with Ear and Brain Anomalies [PDF]
, 2015 Background. Specific clinical conditions could compromise cochlear implantation outcomes and drastically reduce the chance of an acceptable development of perceptual and linguistic capabilities.
Aimoni, C +8 more
core +4 more sources
Waveguide Photoactuators: Materials, Fabrication, and Applications
Advanced Robotics Research, EarlyView.Waveguide photoactuators convert guided light into mechanical motion. Their tethered‐flexible design enables minimally invasive surgery and confined‐space robotics. This review aims to guide materials selection, device design, and system integration, accelerating the transition of waveguide photoactuators from laboratory prototypes to versatile ...
Minjie Xi +4 more
wiley +1 more source
Chaotic Dynamics Enhance the Sensitivity of Inner Ear Hair Cells [PDF]
, 2019 Hair cells of the auditory and vestibular systems are capable of detecting sounds that induce sub-nanometer vibrations of the hair bundle, below the stochastic noise levels of the surrounding fluid.
Bozovic, Dolores, Faber, Justin
core +1 more source
Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear [PDF]
, 2011 RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Jovine, Luca +2 more
core +3 more sources