Results 91 to 100 of about 842,718 (302)
Genomic Analysis of the Function of the Transcription Factor gata3 during Development of the Mammalian Inner Ear [PDF]
, 2009 We have studied the function of the zinc finger transcription factor gata3 in auditory system development by analysing temporal profiles of gene expression during differentiation of conditionally immortal cell lines derived to model specific auditory ...
Lawoko-Kerali, Grace +8 more
core +3 more sources
Flow Phenomena in the Inner Ear [PDF]
, 2019 A remarkable number of different flow phenomena contribute critically to the proper functioning of the hearing and balance senses, both of which are hosted by the inner ear.
Obrist, Dominik
core +1 more source
Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction
Advanced Science, EarlyView.In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng +12 more
wiley +1 more source
Effect of cochlear implant electrode insertion on middle-ear function as measured by intra-operative laser Doppler vibrometry [PDF]
, 2009 Hypothesis: The aim of this study was to investigate the impact of cochlear implant electrode insertion on middle-ear low frequency function in humans.Background: Preservation of residual low frequency hearing with addition of electrical speech ...
Donnelly, N +6 more
core
Progenitor Cells from the Adult Human Inner Ear.
, 2020 Loss of inner ear hair cells leads to incurable balance and hearing disorders because these sensory cells do not effectively regenerate in humans. A potential starting point for therapy would be the stimulation of quiescent progenitor cells within the ...
Volkenstein, Stefan +5 more
core +1 more source
Data‐Driven Design of Self‐Adhesive Epidermal Electrodes and Sensors
Advanced Science, EarlyView.This work presents self‐adhesive, stretchable epidermal electrodes and sensors developed through a data‐driven design framework that integrates artificial neural networks with genetic algorithms. By tailoring optimization objectives, either maximizing electrical conductivity and adhesion or enhancing piezoresistive sensitivity, the study enables the ...
Xuan Li +10 more
wiley +1 more source
Advanced Science, EarlyView.Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo +10 more
wiley +1 more source
Advanced Science, EarlyView.This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang +14 more
wiley +1 more source
, 2018 Inner ear sensory synapses faithfully transduce information over a wide range of stimulus intensities for prolonged periods of time. The efficiency of such demanding and stringent exocytotic activity depends on the presence of specialised presynaptic ...
Sergio Masetto +3 more
core
Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency
Advanced Science, EarlyView.How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen +10 more
wiley +1 more source