Results 81 to 90 of about 842,718 (302)

Otic Neurogenesis Is Regulated by TGFβ in a Senescence-Independent Manner

Frontiers in Cellular Neuroscience, 2020
Cellular senescence has classically been associated with aging. Intriguingly, recent studies have also unraveled key roles for senescence in embryonic development, regeneration, and reprogramming.
Marta Magariños, Marta Magariños, Marta Magariños, Raquel Barajas-Azpeleta, Raquel Barajas-Azpeleta, Isabel Varela-Nieto, Isabel Varela-Nieto, Isabel Varela-Nieto, Maria R. Aburto, Maria R. Aburto   +9 more
doaj   +1 more source

AKT signaling mediates IGF-I survival actions on otic neural progenitors [PDF]

, 2012
Background: Otic neurons and sensory cells derive from common progenitors whose transition into mature cells requires the coordination of cell survival, proliferation and differentiation programmes.
Sanchez-Calderon, Hortensia, Marta Magariños, Leon, Yolanda, Maria R Aburto, Maria R. Aburto (186884), Varela-Nieto, Isabel, Yolanda Leon (5649538), Leon Yolanda, Yolanda Leon, Rodriguez Aburto, Maria, Magariños Marta, Hortensia Sanchez-Calderon, Hortensia Sanchez-Calderon (186893), Isabel Varela-Nieto (186892), Marta Magariños (186888), Aburto Maria R., Isabel Varela-Nieto, Varela-Nieto Isabel, Sanchez-Calderon Hortensia, Magariños, Marta   +19 more
core   +2 more sources

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

On Model-Based Analysis of Ear Biometrics [PDF]

, 2007
Ears are a new biometric with major advantage in that they appear to maintain their structure with increasing age. Most current approaches are holistic and describe the ear by its general properties. We propose a new model-based approach, capitalizing on
Hurley, David, Mark S. Nixon, Nixon, Mark, Arbab-Zavar, Banafshe, David J. Hurley, Banafshe Arbab-Zavar   +5 more
core   +2 more sources

Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish

Biomedicines
Background: Alternative splicing is essential for the physiological and pathological development of the inner ear. Disruptions in this process can result in both syndromic and non-syndromic forms of hearing loss.
Mengmeng Ren, Xiang Chen, Liyan Dai, Jiayi Tu, Hualei Hu, Xiaohan Sun, Jiong Luo, Pei Li, Yiyang Fu, Yuejie Zhu, Weiqiang Sun, Zhaohui Tang, Mugen Liu, Xiang Ren, Qunwei Lu   +14 more
doaj   +1 more source

NOX3-Targeted Therapies for Inner Ear Pathologies

, 2015
Inner ear pathologies are associated with major morbidity and loss of life quality in affected patients. In many of these conditions, production of reactive oxygen-species (ROS) is thought to be a key pathological mechanism.
Senn, Pascal, Krause, Karl-Heinz, Rousset, Francis, Carnesecchi, Stephanie   +3 more
core   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

The Blood-Labyrinth Barrier: Non-Invasive Delivery Strategies for Inner Ear Drug Delivery

Pharmaceutics
The inner ear is a relatively isolated organ, protected by the blood-labyrinth barrier (BLB). This barrier creates a unique lymphatic fluid environment within the inner ear, maintaining a stable physiological state essential for the mechano-electrical ...
Zhangyi Yi, Xiaoying Wang, Ge Yin, Yu Sun   +3 more
doaj   +1 more source

A unique radioprotective effect of resolvin E1 reduces irradiation-induced damage to the inner ear by inhibiting the inflammatory response

Radiation Oncology, 2020
Background In addition to the direct effects of irradiation, the induced inflammatory response may play an important role in the damage to the inner ear caused by radiotherapy for the treatment of head and neck cancers.
Jie Zhang, Anting Xu, Tingting Niu, Chengcheng Liu, Yongju Zhang, Tao Li, Jihua Wang, Yongjing Wang, Dianshui Sun   +8 more
doaj   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source