Results 21 to 30 of about 420,916 (262)

Targeting and Insertion of Membrane Proteins in Mitochondria

Frontiers in Cell and Developmental Biology, 2021
Mitochondrial membrane proteins play an essential role in all major mitochondrial functions. The respiratory complexes of the inner membrane are key for the generation of energy. The carrier proteins for the influx/efflux of essential metabolites to/from
Ross Eaglesfield, Kostas Tokatlidis
doaj   +1 more source

Metalloproteases of the Inner Mitochondrial Membrane [PDF]

Biochemistry, 2017
The inner mitochondrial membrane (IM) is among the most protein-rich cellular compartments. The metastable IM subproteome where the concentration of proteins is approaching oversaturation creates a challenging protein folding environment with a high probability of protein malfunction or aggregation.
Roman M. Levytskyy, Iryna Bohovych, Oleh Khalimonchuk   +2 more
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Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress

Cell Reports, 2016
The mitochondrial inner membrane proteases YME1L and OMA1 are critical regulators of essential mitochondrial functions, including inner membrane proteostasis maintenance and mitochondrial dynamics.
T. Kelly Rainbolt, Justine Lebeau, Cristina Puchades, R. Luke Wiseman   +3 more
doaj   +1 more source

Mutations in Genes with a Role in Cell Envelope Biosynthesis Render Gram-Negative Bacteria Highly Susceptible to the Anti-Infective Small Molecule D66

Microorganisms
Anti-infectives include molecules that target microbes in the context of infection but lack antimicrobial activity under conventional growth conditions.
Samual C. Allgood, Calvin A. Ewing, Weiping Chu, Steffen Porwollik, Michael McClelland, Corrella S. Detweiler   +5 more
doaj   +1 more source

MmpA, a Conserved Membrane Protein Required for Efficient Surface Transport of Trehalose Lipids in Corynebacterineae

Biomolecules, 2021
Cell walls of bacteria of the genera Mycobacterium and Corynebacterium contain high levels of (coryno)mycolic acids. These very long chain fatty acids are synthesized on the cytoplasmic leaflet of the inner membrane (IM) prior to conjugation to the ...
Tamaryn J. Cashmore, Stephan Klatt, Rajini Brammananth, Arek K. Rainczuk, Paul K. Crellin, Malcolm J. McConville, Ross L. Coppel   +6 more
doaj   +1 more source

Evidence for interactions between the mitochondrial import apparatus and respiratory chain complexes via Tim21-like proteins in Arabidopsis.

Frontiers in Plant Science, 2014
The mitochondrial import machinery and the respiratory chain complexes of the inner membrane are highly interdependent for the efficient import and assembly of nuclear encoded respiratory chain components and for the generation of a proton motive force ...
Monika Weronika Murcha, Szymon eKubiszewski-Jakubiak1, Yan eWang, James eWhelan   +3 more
doaj   +1 more source

TMEM65 is a mitochondrial inner-membrane protein [PDF]

PeerJ, 2014
It has been reported that the expression of TMEM65 is regulated by steroid receptor RNA activator (SRA). To date, however, the localization and function of TMEM65 remained unknown. We analyzed the intracellular localization of TMEM65.
Naotaka Nishimura, Tomomi Gotoh, Yuichi Oike, Masato Yano   +3 more
doaj   +2 more sources

Isolation of Inner Membrane Vesicles from Escherichia coli by Using an Affinity Tag

Bio-Protocol, 2012
This protocol was developed in a project aimed to identify the inner membrane proteins localizing to cell poles in Escherichia coli (E. coli). By using a known polar protein Tar as a tag, we isolated pole-derived inner membrane vesicles by affinity ...
Gang Li, Kevin Young
doaj   +1 more source

Bacterial Competition Systems Share a Domain Required for Inner Membrane Transport of the Bacteriocin Pyocin G from Pseudomonas aeruginosa

mBio, 2022
Bacteria exploit a variety of attack strategies to gain dominance within ecological niches. Prominent among these are contact-dependent inhibition (CDI), type VI secretion (T6SS), and bacteriocins.
Iva Atanaskovic, Connor Sharp, Cara Press, Renata Kaminska, Colin Kleanthous   +4 more
doaj   +1 more source

Reconstitutions of mitochondrial inner membrane remodeling

Journal of Structural Biology, 2016
Biological membranes exhibit function-related shapes, leading to a plethora of complex and beautiful cell and cell organellar morphologies. Most if not all of these structures have evolved for a particular physiological reason. The shapes of these structures are formed by physical forces that operate on membranes.
Barbot, Mariam, Meinecke, Michael
openaire   +3 more sources