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Highway to the inner nuclear membrane: rules for the road
Nature Reviews Molecular Cell Biology, 2007To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear pore complex or it must be small enough to pass through by diffusion. Although these principles have long described the nuclear import of soluble proteins, recent evidence indicates that they also apply to the import of integral inner nuclear membrane proteins ...
C Patrick, Lusk +2 more
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Inner nuclear membrane proteins: functions and targeting
Cellular and Molecular Life Sciences, 2001We summarize the properties of integral membrane proteins that reside in the inner nuclear membrane, including lamin B receptor (LBR), lamina-associated polypeptide (LAP) 1, LAP2, emerin, MAN1 and nurim. Most of these proteins interact with lamins and chromatin.
L, Holmer, H J, Worman
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Inner nuclear membrane proteins: impact on human disease
Chromosoma, 2012In the past decade, the inner nuclear membrane has become a focus of research on inherited diseases. A heterogeneous group of genetic disorders known as laminopathies have been described that result from mutations in genes encoding nuclear lamins, intermediate filament proteins associated with the inner nuclear membrane.
Iván, Méndez-López, Howard J, Worman
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Journal of Cell Science, 2022
AbstractAberrant accumulation of inner nuclear membrane (INM) proteins is associated with deformed nuclear morphology and mammalian diseases. However, the mechanisms underlying the maintenance of INM homeostasis remain poorly understood.
Toan Khanh Le +6 more
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AbstractAberrant accumulation of inner nuclear membrane (INM) proteins is associated with deformed nuclear morphology and mammalian diseases. However, the mechanisms underlying the maintenance of INM homeostasis remain poorly understood.
Toan Khanh Le +6 more
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Inner nuclear membrane and signal transduction
Journal of Cellular Biochemistry, 2005AbstractRecent research has shown that the inner nuclear membrane is a site for regulation of signal transduction from the plasma membrane to the nucleus. This has coincided with discoveries showing that mutations in extrinsic and intrinsic inner nuclear membrane proteins cause a variety of inherited diseases. In most instances, the mechanisms by which
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Inner nuclear membrane proteins and the nuclear lamina
Journal of Cell Science, 2001The nuclear lamina is a scaffolding structure at the nuclear periphery and is required for maintenance of nuclear shape, spacing of nuclear pore complexes, organization of heterochromatin, DNA replication, and regulation of transcription factors.
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Inner nuclear membrane and regulation of Smad-mediated signaling
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006Smads mediate signal transduction by cytokines of the transforming growth factor-beta family. Recent data show that intrinsic and extrinsic proteins of the inner nuclear membrane affect the activities of Smads. MAN1, an integral protein of the inner nuclear membrane, binds to receptor-regulated Smads and antagonizes signaling by transforming growth ...
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Establishment of NE asymmetry — targeting of membrane proteins to the inner nuclear membrane
Current Opinion in Cell Biology, 2015The inner nuclear membrane (INM) represents a specialized subdomain of the endoplasmic reticulum (ER). The INM houses a unique set of integral membrane proteins that perform key functions in the organization of intranuclear architecture, control of gene expression and coupling of the nucleus to the cytoskeleton.
Rosemarie Ungricht, Ulrike Kutay
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Characterization of Inner Nuclear Membrane Proteins
GBM Annual Fall meeting Halle 2002, 2002Henning Otto +3 more
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